The significance of the ratio in follicle-stimulating hormone and luteinizing hormone in induction of multiple follicular growth

R. E. Bernardus, G. S. Jones, A. A. Acosta, J. E. Garcia, H. C. Liu, Z. Rosenwaks

Research output: Contribution to journalArticlepeer-review

Abstract

Among the patients enrolled in the Norfolk In Vitro Fertilization Program there were 32 who had been stimulated according to the basic stimulation protocol using two ampules of human menopausal gonadotropin (hMG) daily. Because of their inadequate response, 23 of these 32 patients were stimulated subsequently with a combination of two ampules of 'pure' follicle-stimulating hormone (FSH) and two ampules of hMG on cycle days 3 and 4. The remaining nine patients received four ampules of 'pure' FSH only on cycle days 3 and 4. Stimulation was continued with hMG in both FSH regimens. Ten thousand units of human chorionic gonadotropin was used for final maturation. Parallel with the increase in the ratio of exogenous FSH to luteinizing hormone, an increase in oocyte recovery was observed, as well as an improvement in transfer and pregnancy rates. It was concluded that FSH enrichment had a beneficial effect in these patients.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalFertility and sterility
Volume43
Issue number3
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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