TY - JOUR
T1 - The short and long telomere syndromes
T2 - Paired paradigms for molecular medicine
AU - Stanley, Susan E.
AU - Armanios, Mary
N1 - Funding Information:
We are grateful to a number of colleagues for helpful comments on this manuscript. Work in our lab is supported by the National Institutes of Health ( RO1 HL119476 and RO1 CA160433 ), the Commonwealth Foundation and the Flight Attendants Medical Research Institute . The authors declare no conflict of interest.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Recent advances have defined a role for abnormally short telomeres in a broad spectrum of genetic disorders. They include rare conditions such as dyskeratosis congenita as well pulmonary fibrosis and emphysema. Now, there is new evidence that some familial cancers, such as melanoma, are caused by mutations that lengthen telomeres. Here, we examine the significance of these short and long telomere length extremes for understanding the molecular basis of age-related disease and cancer.
AB - Recent advances have defined a role for abnormally short telomeres in a broad spectrum of genetic disorders. They include rare conditions such as dyskeratosis congenita as well pulmonary fibrosis and emphysema. Now, there is new evidence that some familial cancers, such as melanoma, are caused by mutations that lengthen telomeres. Here, we examine the significance of these short and long telomere length extremes for understanding the molecular basis of age-related disease and cancer.
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U2 - 10.1016/j.gde.2015.06.004
DO - 10.1016/j.gde.2015.06.004
M3 - Review article
C2 - 26232116
AN - SCOPUS:84938086280
SN - 0959-437X
VL - 33
SP - 1
EP - 9
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -