TY - JOUR
T1 - The shape of the concentration–response association between fine particulate matter pollution and human mortality in Beijing, China, and its implications for health impact assessment
AU - Yan, Meilin
AU - Wilson, Ander
AU - Bell, Michelle L.
AU - Peng, Roger D.
AU - Sun, Qinghua
AU - Pu, Weiwei
AU - Yin, Xiaomei
AU - Li, Tiantian
AU - Anderson, G. Brooke
N1 - Funding Information:
This research was supported by the National Key Research and Development (R&D) Program of China under award number 2016 YFC 0201902, the National Science Foundation of China under award number 41475135, the National Institute of Environmental Health Sciences under award number R00ES022631, the National Institute On Minority Health And Health Disparities of the National Institutes of Health under award number R01MD012769, and the U.S. Environmental Protection Agency (U.S. EPA) under Assistance Agreement No. RD835871 awarded to Yale University.
Funding Information:
This research was supported by the National Key Research and Development (R&D) Program of China under award number 2016 YFC 0201902, the National Science Foundation of China under award number 41475135, the National Institute of Environmental Health Sciences under award number R00ES022631, the National Institute On Minority Health And Health Disparities of the National Institutes of Health under award number R01MD012769, and the U.S. Environmental Protection Agency (U.S. EPA) under Assistance Agreement No. RD835871 awarded to Yale University. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the U.S. EPA. It has not been formally reviewed by the U.S. EPA. The U.S. EPA does not endorse any products or commercial services mentioned in this publication.
Publisher Copyright:
© 2019, Public Health Services, US Dept of Health and Human Services. All rights reserved.
PY - 2019/6
Y1 - 2019/6
N2 - BACKGROUND: Studies found approximately linear short-term associations between particulate matter (PM) and mortality in Western communities. However, in China, where the urban PM levels are typically considerably higher than in Western communities, some studies suggest nonlinearity in this association. Health impact assessments (HIA) of PM in China have generally not incorporated nonlinearity in the concentration–response (C-R) association, which could result in large discrepancies in estimates of excess deaths if the true association is nonlinear. OBJECTIVES: We investigated nonlinearity in the C-R associations between with PM with aerodynamic diameter ≤2:5 lm (PM2:5) and mortality in Beijing, China, and the sensitivity of HIA to linearity assumptions. METHODS: We modeled the C-R association between PM2:5 and cause-specific mortality in Beijing, China (2009–2012), using generalized linear models (GLM). PM2:5 was included through either linear, piecewise-linear, or spline functions to investigate evidence of nonlinearity. To determine the sensitivity of HIA to linearity assumptions, we estimated PM2:5-attributable deaths using both linear-and nonlinear-based C-R associations between PM2:5 and mortality. RESULTS: We found some evidence that, for nonaccidental and circulatory mortality, the shape of the C-R association was relatively flat at lower concentrations of PM2:5, but then had a positive slope at higher concentrations, indicating nonlinearity. Conversely, the shape for respiratory mortality was positive and linear at lower concentrations of PM2:5, but then leveled off at the higher concentrations. Estimates of excess deaths attributable to short-term PM2:5 exposure were, in some cases, very sensitive to the linearity assumption in the association, but in other cases robust to this assumption. CONCLUSIONS: Our results demonstrate some evidence of nonlinearity in PM2:5 –mortality associations and that an assumption of linearity in this association can influence HIAs, highlighting the importance of understanding potential nonlinearity in the PM2:5 –mortality association at the high concentrations of PM2:5 in developing megacities like Beijing. https://doi.org/10.1289/EHP4464.
AB - BACKGROUND: Studies found approximately linear short-term associations between particulate matter (PM) and mortality in Western communities. However, in China, where the urban PM levels are typically considerably higher than in Western communities, some studies suggest nonlinearity in this association. Health impact assessments (HIA) of PM in China have generally not incorporated nonlinearity in the concentration–response (C-R) association, which could result in large discrepancies in estimates of excess deaths if the true association is nonlinear. OBJECTIVES: We investigated nonlinearity in the C-R associations between with PM with aerodynamic diameter ≤2:5 lm (PM2:5) and mortality in Beijing, China, and the sensitivity of HIA to linearity assumptions. METHODS: We modeled the C-R association between PM2:5 and cause-specific mortality in Beijing, China (2009–2012), using generalized linear models (GLM). PM2:5 was included through either linear, piecewise-linear, or spline functions to investigate evidence of nonlinearity. To determine the sensitivity of HIA to linearity assumptions, we estimated PM2:5-attributable deaths using both linear-and nonlinear-based C-R associations between PM2:5 and mortality. RESULTS: We found some evidence that, for nonaccidental and circulatory mortality, the shape of the C-R association was relatively flat at lower concentrations of PM2:5, but then had a positive slope at higher concentrations, indicating nonlinearity. Conversely, the shape for respiratory mortality was positive and linear at lower concentrations of PM2:5, but then leveled off at the higher concentrations. Estimates of excess deaths attributable to short-term PM2:5 exposure were, in some cases, very sensitive to the linearity assumption in the association, but in other cases robust to this assumption. CONCLUSIONS: Our results demonstrate some evidence of nonlinearity in PM2:5 –mortality associations and that an assumption of linearity in this association can influence HIAs, highlighting the importance of understanding potential nonlinearity in the PM2:5 –mortality association at the high concentrations of PM2:5 in developing megacities like Beijing. https://doi.org/10.1289/EHP4464.
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U2 - 10.1289/EHP4464
DO - 10.1289/EHP4464
M3 - Article
C2 - 31170008
AN - SCOPUS:85067488871
VL - 127
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 6
M1 - 067007
ER -