TY - JOUR
T1 - The sex combs reduced gene of drosophila melanogaster has multiple transcripts
AU - Andrew, Deborah J.
N1 - Funding Information:
1 thank the American Cancer Society for providing my postdoctoral fellowship. I am grateful to D. Barrick for critical comments on the manuscript. I thank Fran Storfer, who isolated the cDNA clones from the Kauvar D. melanogaster embryonic cDNA libraries. This research was supported by N.I.H. grant No. 18163 to Matthew P. Scott in whose laboratory this work was carried out. Both genomic and cDNA sequences are available through GenBank and EMBL data bases under accession Nos. X77074, X77075, X77076 and X76987. Clones and sequence data from the D. virilis Scr gene are available upon request.
PY - 1995/1/23
Y1 - 1995/1/23
N2 - The Sex combs reduced (Scr) homeotic gene of Drosophila melanogaster specifies the development of structures within the most posterior head segment, the labium and the most anterior thoracic segment, the prothorax or Tl. Here, the structure of Scr and correct sequence of the SCR protein are presented. Scr encodes a 417-amino-acid DNA-binding protein with sequence similarity to the mouse homologues, HOXA5, B5 and C5. The greatest similarity is within the DNA-binding homeodomain (hdm); shorter conserved motifs are found near the N terminus and a region N-terminal to the hdm. As with most of the D. melanogaster homeotic genes, Scr has alternative exons.
AB - The Sex combs reduced (Scr) homeotic gene of Drosophila melanogaster specifies the development of structures within the most posterior head segment, the labium and the most anterior thoracic segment, the prothorax or Tl. Here, the structure of Scr and correct sequence of the SCR protein are presented. Scr encodes a 417-amino-acid DNA-binding protein with sequence similarity to the mouse homologues, HOXA5, B5 and C5. The greatest similarity is within the DNA-binding homeodomain (hdm); shorter conserved motifs are found near the N terminus and a region N-terminal to the hdm. As with most of the D. melanogaster homeotic genes, Scr has alternative exons.
KW - Antennapedia complex
KW - Homeotic gene
KW - alternative transcripts
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U2 - 10.1016/0378-1119(94)00642-6
DO - 10.1016/0378-1119(94)00642-6
M3 - Article
C2 - 7835693
AN - SCOPUS:0028939365
SN - 0378-1119
VL - 152
SP - 149
EP - 155
JO - Gene
JF - Gene
IS - 2
ER -