The sensitivity of an actinic reticuloid cell strain to near‐ultraviolet radiation and its modification by Trolox‐C, a vitamin E analogue

A. KRALLI, S. H. MOSS

Research output: Contribution to journalArticlepeer-review

Abstract

Near‐UV radiation (365 nm)‐induced lethality, as measured by colony‐forming ability, showed an actinic reticuloid cell strain to be sensitive relative to normal human fibroblasts, when irradiated at 25° C. This effect was not seen after far‐UV (254 nm) irradiation. Trolox‐C, a water‐soluble analogue of vitamin E, incorporated in the pre‐irradiation growth medium or in the post‐irradiation plating medium, protected the actinic reticuloid cells to the extent that they were as resistant as normal cells. Plating medium containing Trolox‐C did not provide differential protection against inactivation of the two cell strains by wavelengths in the far‐UV region. The protection provided by Trolox‐C, an analogue of the natural antioxidant vitamin E, suggests some free radical involvement in the actiology of the disease.

Original languageEnglish (US)
Pages (from-to)761-772
Number of pages12
JournalBritish Journal of Dermatology
Volume116
Issue number6
DOIs
StatePublished - Jun 1987
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'The sensitivity of an actinic reticuloid cell strain to near‐ultraviolet radiation and its modification by Trolox‐C, a vitamin E analogue'. Together they form a unique fingerprint.

Cite this