Near‐UV radiation (365 nm)‐induced lethality, as measured by colony‐forming ability, showed an actinic reticuloid cell strain to be sensitive relative to normal human fibroblasts, when irradiated at 25° C. This effect was not seen after far‐UV (254 nm) irradiation. Trolox‐C, a water‐soluble analogue of vitamin E, incorporated in the pre‐irradiation growth medium or in the post‐irradiation plating medium, protected the actinic reticuloid cells to the extent that they were as resistant as normal cells. Plating medium containing Trolox‐C did not provide differential protection against inactivation of the two cell strains by wavelengths in the far‐UV region. The protection provided by Trolox‐C, an analogue of the natural antioxidant vitamin E, suggests some free radical involvement in the actiology of the disease.
|Original language||English (US)|
|Number of pages||12|
|Journal||British Journal of Dermatology|
|State||Published - Jun 1987|
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