The sensation of angina can be evoked by stimulation of the human thalamus

Frederick Lenz, Richard H. Gracely, Earl J. Hope, Frank H. Baker, Lance H. Rowland, Patrick M. Dougherty, Russell T. Richardson

Research output: Contribution to journalArticle

Abstract

We have performed single-neuron recording and microstimulation in the region of the thalamic principal sensory nucleus (ventrocaudal nucleus, Vc) prior to implantation of a deep brain-stimulating electrode in a patient with pain secondary to arachnoiditis and with a past history of unstable angina. Cells located in the 16 mm lateral plane had cutaneous receptive fields on the chest wall. At and posterior to the location of these cells stimulation coincided precisely with the sensation of angina (stimulation-associated angina). The description of stimulation-associated angina was measured using a questionnaire and was identical to the patient's usual angina except that it began and terminated suddenly. Stimulation-associated angina was coincident with a tingling sensation in the leg. Clinical, hemodynamic, electrophysiologic and biochemical measures of cardiac function showed no evidence of myocardial strain or injury related to stimulation-associated angina. Since cells in the region of the principle sensory nucleus of thalamus respond to cardiac injury in animals, the present results suggest that this region mediates the sensation of angina.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalPain
Volume59
Issue number1
DOIs
StatePublished - 1994

Fingerprint

Thalamus
Arachnoiditis
Unstable Angina
Wounds and Injuries
Thoracic Wall
Leg
Electrodes
Hemodynamics
Neurons
Pain
Skin
Brain

Keywords

  • Angina pectoris
  • Electrical stimulation
  • Neuron
  • Pain measurement
  • Ventral posterior thalamic nucleus
  • Visceral pain

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

Cite this

Lenz, F., Gracely, R. H., Hope, E. J., Baker, F. H., Rowland, L. H., Dougherty, P. M., & Richardson, R. T. (1994). The sensation of angina can be evoked by stimulation of the human thalamus. Pain, 59(1), 119-125. https://doi.org/10.1016/0304-3959(94)90055-8

The sensation of angina can be evoked by stimulation of the human thalamus. / Lenz, Frederick; Gracely, Richard H.; Hope, Earl J.; Baker, Frank H.; Rowland, Lance H.; Dougherty, Patrick M.; Richardson, Russell T.

In: Pain, Vol. 59, No. 1, 1994, p. 119-125.

Research output: Contribution to journalArticle

Lenz, F, Gracely, RH, Hope, EJ, Baker, FH, Rowland, LH, Dougherty, PM & Richardson, RT 1994, 'The sensation of angina can be evoked by stimulation of the human thalamus', Pain, vol. 59, no. 1, pp. 119-125. https://doi.org/10.1016/0304-3959(94)90055-8
Lenz F, Gracely RH, Hope EJ, Baker FH, Rowland LH, Dougherty PM et al. The sensation of angina can be evoked by stimulation of the human thalamus. Pain. 1994;59(1):119-125. https://doi.org/10.1016/0304-3959(94)90055-8
Lenz, Frederick ; Gracely, Richard H. ; Hope, Earl J. ; Baker, Frank H. ; Rowland, Lance H. ; Dougherty, Patrick M. ; Richardson, Russell T. / The sensation of angina can be evoked by stimulation of the human thalamus. In: Pain. 1994 ; Vol. 59, No. 1. pp. 119-125.
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