The Selective Inhibition of Secondary IgE Antibody Response in Mice by Dibutyryl Adenosine 3′,5′-Cyclic Monophosphoric Acid and Theophylline

The effect of various agents on the in vivo anamnestic IgE and IgG responses of mice to alum suspensions of ovalbumin was determined. Dibutyryl cAMP and theophylline inhibited IgE but not IgG synthesis, whereas other immunosuppressive drugs inhibited both antibody classes equally. Previous reports have suggested separate pathways for the synthesis of IgG and IgE, and this report suggests that the IgE response can be selectively inhibited.