The second human calcitonin/CGRP gene is located on chromosome 11

J. W.M. Höppener, P. H. Steenbergh, J. Zandberg, A. H.M. Geurts van Kessel, S. B. Baylin, B. D. Nelkin, H. S. Jansz, C. J.M. Lips

Research output: Contribution to journalArticle

Abstract

A second human calcitonin/calcitonin gene related peptide (hCT/CGRP) gene has been identified. This second hCT/CGRP gene has been shown to contain sequences highly homologous to exons 3, 5 (CGRP-encoding), and 6 of the first hCT/CGRP gene, but sequences closely related to exon 4 (CT-encoding) could not be demonstrated. Southern blot hybridization analysis of DNA from human-rodent somatic cell hybrids showed that the second hCT/CGRP gene is located in the q12-pter region of chromosome 11. The first hCT/CGRP gene has previously been assigned to the p13-p15 region of chromosome 11.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalHuman genetics
Volume70
Issue number3
DOIs
StatePublished - Jul 1 1985

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Höppener, J. W. M., Steenbergh, P. H., Zandberg, J., Geurts van Kessel, A. H. M., Baylin, S. B., Nelkin, B. D., Jansz, H. S., & Lips, C. J. M. (1985). The second human calcitonin/CGRP gene is located on chromosome 11. Human genetics, 70(3), 259-263. https://doi.org/10.1007/BF00273453