The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins

Frank Bosmans, Abel Aneiros, Jan Tytgat

Research output: Contribution to journalArticle

Abstract

Two sodium channel toxins, BgII and BgIII, isolated from the sea anemone Bunodosoma granulifera, have been subjected to an elaborate electrophysiological and pharmacological comparison between five different cloned sodium channels expressed in Xenopus laevis oocytes in order to determine their efficacy, potency and selectivity. Our results reveal large differences in toxin-induced effect between the different sodium channels. These toxins possess the highest efficacy for the insect sodium channel (para). Our data also show that BgII, generally known as a neurotoxin, is especially potent on the insect sodium channel with an EC50 value of 5.5±0.5 nM. Therefore, this toxin can be used as a template for further development of new insecticides. Based on our findings, an evolutionary relationship between crustaceans and insects is also discussed.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalFEBS Letters
Volume532
Issue number1-2
DOIs
StatePublished - Dec 4 2002

Keywords

  • Evolution
  • Insecticide
  • Neurotoxin
  • Sea anemone toxin
  • Voltage-gated sodium channel

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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