The Scottish Heart Health Study. Dietary intake by food frequency questionnaire and odds ratios for coronary heart disease risk. II. The antioxidant vitamins and fibre

C. Bolton-Smith, M. Woodward, H. Tunstall-Pedoe

Research output: Contribution to journalArticle

Abstract

High serum antioxidant vitamins are increasingly being associated with reduced risk of coronary heart disease (CHD). Previous studies have not addressed the relationship between dietary antioxidant vitamins and risk of CHD although diet is a key factor which modifies blood antioxidant vitamin levels. In prospective studies, high-fibre diets have also been associated with reduced CHD incidence. In this analysis CHD-diagnosed, -undiagnosed and non-CHD controls were selected from 10359 men and women aged 40-59 who participated in a cross-sectional study of CHD risk factors. Diet was assessed by food frequency questionnaire, odds ratios were adjusted for the classical CHD risk factors (± social class) and calculated relative to the first quintile for each vitamin and total fibre. The antioxidant vitamins were further combined in a principal component analysis and the odds ratios for undiagnosed and diagnosed CHD were again calculated. For undiagnosed CHD risk was significantly lower in the highest quintiles of β-carotene, fibre and vitamin C, E and A for men, but only lower for fibre in women. Opposite trends were observed in the odds ratios for vitamin C and E and fibre for male-diagnosed CHD which possibly indicates changes in diet as a result of diagnosis. Principal component analysis showed significantly reduced risk of undiagnosed CHD in the top three quintiles for men (odds ratios 0.66, 0.67 and 0.64; P <0.05 in each case). A similar trend occurred for women but was non-significant. The results suggest that high dietary intake of the antioxidant vitamins may reduce risk of CHD, particularly in men, and that fibre may be equally cardio-protective in both sexes.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalEuropean Journal of Clinical Nutrition
Volume46
Issue number2
StatePublished - 1992
Externally publishedYes

Fingerprint

food frequency questionnaires
Vitamins
odds ratio
Coronary Disease
vitamins
food intake
dietary fiber
Eating
Antioxidants
Odds Ratio
heart
antioxidants
Health
Diet
Principal Component Analysis
Vitamin E
Ascorbic Acid
principal component analysis
coronary disease
Surveys and Questionnaires

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

The Scottish Heart Health Study. Dietary intake by food frequency questionnaire and odds ratios for coronary heart disease risk. II. The antioxidant vitamins and fibre. / Bolton-Smith, C.; Woodward, M.; Tunstall-Pedoe, H.

In: European Journal of Clinical Nutrition, Vol. 46, No. 2, 1992, p. 85-93.

Research output: Contribution to journalArticle

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