The Science and (Lost) Art of Psoralen Plus UVA Phototherapy

Research output: Contribution to journalReview articlepeer-review


PUVA phototherapy is the therapeutic use of psoralens and UVA light to treat inflammatory skin diseases, with psoriasis the prototype disease. Naturally occurring phototoxic compounds, psoralens interact with UVA to suppress DNA synthesis and cell proliferation and induce apoptosis of inflammatory cells. Well-developed therapeutic protocols for psoriasis guide psoralen and UVA doses, treatment frequency, and safety measures, and these protocols also may be used to treat other inflammatory dermatoses.

Original languageEnglish (US)
Pages (from-to)11-23
Number of pages13
JournalDermatologic clinics
Issue number1
StatePublished - Jan 2020


  • Dermatitis
  • PUVA
  • Photochemotherapy
  • Psoralen
  • Psoriasis
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology


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