The schizophrenia syndrome. Examples of biological tools for subclassification

R. J. Wyatt, S. G. Potkin, J. E. Kleinman, D. R. Weinberger, D. J. Luchins, D. V. Jeste

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Six biological variables - platelet monoamine oxidase activity, urine phenylethylamine concentration, brain norepinephrine concentration, abnormalities on computerized tomography, lateralization asymmetries, and the presence or absence of tardive dyskinesia - are used to discriminate possible biological groups of schizophrenic patients. All variables successfully subclassify patients, some into divisions consistent with phenomenological, psychosocial, or biochemical descriptions or hypotheses of schizophrenia. None of the measures, however, has sufficiently stood the test of time to be of clinical utility.

Original languageEnglish (US)
Pages (from-to)100-112
Number of pages13
JournalUnknown Journal
Issue number2
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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