The same "TATA" box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation

Shangzhi Huang, Corinne Wong, Stylianos E. Antonarakis, Tsai Ro-lien, Wilson H Y Lo, Haig Kazazian

Research output: Contribution to journalArticle


A Chinese β+-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.

Original languageEnglish (US)
Pages (from-to)162-164
Number of pages3
JournalHuman Genetics
Issue number2
StatePublished - Oct 1986


ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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