The same "TATA" box β-thalassemia mutation in Chinese and US blacks

another example of independent origins of mutation

Shangzhi Huang, Corinne Wong, Stylianos E. Antonarakis, Tsai Ro-lien, Wilson H Y Lo, Haig Kazazian

Research output: Contribution to journalArticle

Abstract

A Chinese β+-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.

Original languageEnglish (US)
Pages (from-to)162-164
Number of pages3
JournalHuman Genetics
Volume74
Issue number2
DOIs
StatePublished - Oct 1986

Fingerprint

TATA Box
Thalassemia
Mutation
Globins
Ethnic Groups
Haplotypes
Genes
Organism Cloning

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

The same "TATA" box β-thalassemia mutation in Chinese and US blacks : another example of independent origins of mutation. / Huang, Shangzhi; Wong, Corinne; Antonarakis, Stylianos E.; Ro-lien, Tsai; Lo, Wilson H Y; Kazazian, Haig.

In: Human Genetics, Vol. 74, No. 2, 10.1986, p. 162-164.

Research output: Contribution to journalArticle

Huang, Shangzhi ; Wong, Corinne ; Antonarakis, Stylianos E. ; Ro-lien, Tsai ; Lo, Wilson H Y ; Kazazian, Haig. / The same "TATA" box β-thalassemia mutation in Chinese and US blacks : another example of independent origins of mutation. In: Human Genetics. 1986 ; Vol. 74, No. 2. pp. 162-164.
@article{33342999888343ffba9e7367cc07019f,
title = "The same {"}TATA{"} box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation",
abstract = "A Chinese β+-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.",
author = "Shangzhi Huang and Corinne Wong and Antonarakis, {Stylianos E.} and Tsai Ro-lien and Lo, {Wilson H Y} and Haig Kazazian",
year = "1986",
month = "10",
doi = "10.1007/BF00282081",
language = "English (US)",
volume = "74",
pages = "162--164",
journal = "Human Genetics",
issn = "0340-6717",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - The same "TATA" box β-thalassemia mutation in Chinese and US blacks

T2 - another example of independent origins of mutation

AU - Huang, Shangzhi

AU - Wong, Corinne

AU - Antonarakis, Stylianos E.

AU - Ro-lien, Tsai

AU - Lo, Wilson H Y

AU - Kazazian, Haig

PY - 1986/10

Y1 - 1986/10

N2 - A Chinese β+-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.

AB - A Chinese β+-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.

UR - http://www.scopus.com/inward/record.url?scp=0022905359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022905359&partnerID=8YFLogxK

U2 - 10.1007/BF00282081

DO - 10.1007/BF00282081

M3 - Article

VL - 74

SP - 162

EP - 164

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 2

ER -