The same "TATA" box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation

Shangzhi Huang; Corinne Wong; Stylianos E. Antonarakis; Tsai Ro-lien; Wilson H.Y. Lo; Haig H. Kazazian

doi:10.1007/BF00282081

The same "TATA" box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation

Shangzhi Huang, Corinne Wong, Stylianos E. Antonarakis, Tsai Ro-lien, Wilson H.Y. Lo, Haig H. Kazazian

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A Chinese β⁺-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.

Original language	English (US)
Pages (from-to)	162-164
Number of pages	3
Journal	Human genetics
Volume	74
Issue number	2
DOIs	https://doi.org/10.1007/BF00282081
State	Published - Oct 1 1986

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1007/BF00282081

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abstract = "A Chinese β+-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.",

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AU - Kazazian, Haig H.

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