The same "TATA" box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation

Shangzhi Huang, Corinne Wong, Stylianos E. Antonarakis, Tsai Ro-lien, Wilson H.Y. Lo, Haig H. Kazazian

Research output: Contribution to journalArticlepeer-review

Abstract

A Chinese β+-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.

Original languageEnglish (US)
Pages (from-to)162-164
Number of pages3
JournalHuman genetics
Volume74
Issue number2
DOIs
StatePublished - Oct 1 1986

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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