The same "TATA" box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation

Shangzhi Huang; Corinne Wong; Stylianos E. Antonarakis; Tsai Ro-lien; Wilson H Y Lo; Haig Kazazian

doi:10.1007/BF00282081

The same "TATA" box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation

Shangzhi Huang, Corinne Wong, Stylianos E. Antonarakis, Tsai Ro-lien, Wilson H Y Lo, Haig Kazazian

School of Medicine

Research output: Contribution to journal › Article

Abstract

A Chinese β⁺-thalassemia gene in a new haplotype was chosen for cloning and sequencing. The mutation identified was an A-G transition at position-29 in the TATA box of the β-globin gene. This mutation has not been seen previously in Chinese but has been documented in American blacks on a different chromosomal background. This observation provides further evidence for independent origins of the same mutation in distinct ethnic groups.

Original language	English (US)
Pages (from-to)	162-164
Number of pages	3
Journal	Human Genetics
Volume	74
Issue number	2
DOIs	https://doi.org/10.1007/BF00282081
State	Published - Oct 1986

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ASJC Scopus subject areas

Genetics(clinical)
Genetics

Cite this

Huang, S., Wong, C., Antonarakis, S. E., Ro-lien, T., Lo, W. H. Y., & Kazazian, H. (1986). The same "TATA" box β-thalassemia mutation in Chinese and US blacks: another example of independent origins of mutation. Human Genetics, 74(2), 162-164. https://doi.org/10.1007/BF00282081

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Access to Document

10.1007/BF00282081