The RPE Cell and the Immune System

Barbara Detrick; John J. Hooks

doi:10.1007/978-3-030-28384-1_6

The RPE Cell and the Immune System

Barbara Detrick, John J. Hooks

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The RPE cell plays a pivotal role in retinal immunity. In fact, the RPE cell orchestrates both innate and adaptive immunity and contains a plethora of factors to regulate the immune response. Many immunoregulatory activities of the RPE cell are accomplished through cytokine production, toll-like receptor (TLR) activation, complement regulation and antigen presentation. The RPE cells immune regulatory network plays an essential role in retinal immunity and autoimmunity, retinal infections and in a variety of retinal degenerative disorders. Understanding the immune regulatory properties of this cell may provide additional clues to disease mechanisms that may lead to future treatments for many human retinal diseases.

Original language	English (US)
Title of host publication	Retinal Pigment Epithelium in Health and Disease
Publisher	Springer International Publishing
Pages	101-114
Number of pages	14
ISBN (Electronic)	9783030283841
ISBN (Print)	9783030283834
DOIs	https://doi.org/10.1007/978-3-030-28384-1_6
State	Published - Jan 1 2020

Keywords

Adaptive immunity
Antigen presenting cell
Cytokines
Inflammation
Innate immunity

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-3-030-28384-1_6

Cite this

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AB - The RPE cell plays a pivotal role in retinal immunity. In fact, the RPE cell orchestrates both innate and adaptive immunity and contains a plethora of factors to regulate the immune response. Many immunoregulatory activities of the RPE cell are accomplished through cytokine production, toll-like receptor (TLR) activation, complement regulation and antigen presentation. The RPE cells immune regulatory network plays an essential role in retinal immunity and autoimmunity, retinal infections and in a variety of retinal degenerative disorders. Understanding the immune regulatory properties of this cell may provide additional clues to disease mechanisms that may lead to future treatments for many human retinal diseases.

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ER -

The RPE Cell and the Immune System

Abstract

Keywords

ASJC Scopus subject areas

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