The RPE Cell and the Immune System

Barbara Detrick, John J. Hooks

Research output: Chapter in Book/Report/Conference proceedingChapter


The RPE cell plays a pivotal role in retinal immunity. In fact, the RPE cell orchestrates both innate and adaptive immunity and contains a plethora of factors to regulate the immune response. Many immunoregulatory activities of the RPE cell are accomplished through cytokine production, toll-like receptor (TLR) activation, complement regulation and antigen presentation. The RPE cells immune regulatory network plays an essential role in retinal immunity and autoimmunity, retinal infections and in a variety of retinal degenerative disorders. Understanding the immune regulatory properties of this cell may provide additional clues to disease mechanisms that may lead to future treatments for many human retinal diseases.

Original languageEnglish (US)
Title of host publicationRetinal Pigment Epithelium in Health and Disease
PublisherSpringer International Publishing
Number of pages14
ISBN (Electronic)9783030283841
ISBN (Print)9783030283834
StatePublished - Jan 1 2020


  • Adaptive immunity
  • Antigen presenting cell
  • Cytokines
  • Inflammation
  • Innate immunity

ASJC Scopus subject areas

  • Medicine(all)


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