The Roles of Reward, Default, and Executive Control Networks in Set-Shifting Impairments in Schizophrenia

James A. Waltz, Zuzana Kasanova, Thomas J. Ross, Betty J. Salmeron, Robert P. McMahon, James M. Gold, Elliot A. Stein

Research output: Contribution to journalArticle

Abstract

Patients with schizophrenia (SZ) show deficits on tasks of rapid reinforcement learning, like probabilistic reversal learning (PRL), but the neural bases for those impairments are not known. Recent evidence of relatively intact sensitivity to negative outcomes in the ventral striatum (VS) in many SZ patients suggests that PRL deficits may be largely attributable to processes downstream from feedback processing, involving both the activation of executive control task regions and deactivation of default mode network (DMN) components. We analyzed data from 29 chronic SZ patients and 21 matched normal controls (NCs) performing a PRL task in an MRI scanner. Subjects were presented with eight pairs of fractal stimuli, for 50 trials each. For each pair, subjects learned to choose the more frequently-rewarded (better) stimulus. Each time a criterion was reached, the better stimulus became the worse one, and the worse became the better. Responses to feedback events were assessed through whole-brain and regions-of-interest (ROI) analyses in DMN. We also assessed correlations between BOLD signal contrasts and clinical measures in SZs. Relative to NCs, SZ patients showed comparable deactivation of VS in response to negative feedback, but reduced deactivation of DMN components including medial prefrontal cortex (mPFC). The magnitudes of patients' punishment-evoked deactivations in VS and ventromedial PFC correlated significantly with clinical ratings for avolition/anhedonia. These findings suggest that schizophrenia is associated with a reduced ability to deactivate components of default mode networks, following the presentation of informative feedback and that motivational deficits in SZ relate closely to feedback-evoked activity in reward circuit components. These results also confirm a role for ventrolateral and dorsomedial PFC in the execution of response-set shifts.

Original languageEnglish (US)
Article numbere57257
JournalPLoS One
Volume8
Issue number2
DOIs
StatePublished - Feb 27 2013
Externally publishedYes

Fingerprint

Executive Function
Reward
Schizophrenia
Reversal Learning
Feedback
learning
Network components
Anhedonia
Reinforcement learning
Fractals
Aptitude
Punishment
Magnetic resonance imaging
scanners
Prefrontal Cortex
Brain
Chemical activation
schizophrenia
Learning
Networks (circuits)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Waltz, J. A., Kasanova, Z., Ross, T. J., Salmeron, B. J., McMahon, R. P., Gold, J. M., & Stein, E. A. (2013). The Roles of Reward, Default, and Executive Control Networks in Set-Shifting Impairments in Schizophrenia. PLoS One, 8(2), [e57257]. https://doi.org/10.1371/journal.pone.0057257

The Roles of Reward, Default, and Executive Control Networks in Set-Shifting Impairments in Schizophrenia. / Waltz, James A.; Kasanova, Zuzana; Ross, Thomas J.; Salmeron, Betty J.; McMahon, Robert P.; Gold, James M.; Stein, Elliot A.

In: PLoS One, Vol. 8, No. 2, e57257, 27.02.2013.

Research output: Contribution to journalArticle

Waltz, JA, Kasanova, Z, Ross, TJ, Salmeron, BJ, McMahon, RP, Gold, JM & Stein, EA 2013, 'The Roles of Reward, Default, and Executive Control Networks in Set-Shifting Impairments in Schizophrenia', PLoS One, vol. 8, no. 2, e57257. https://doi.org/10.1371/journal.pone.0057257
Waltz, James A. ; Kasanova, Zuzana ; Ross, Thomas J. ; Salmeron, Betty J. ; McMahon, Robert P. ; Gold, James M. ; Stein, Elliot A. / The Roles of Reward, Default, and Executive Control Networks in Set-Shifting Impairments in Schizophrenia. In: PLoS One. 2013 ; Vol. 8, No. 2.
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