TY - JOUR
T1 - The Role of Whole-Body MRI in Pediatric Musculoskeletal Oncology
T2 - Current Concepts and Clinical Applications
AU - Guimarães, Júlio Brandão
AU - da Cruz, Isabela Azevedo Nicodemos
AU - Ahlawat, Shivani
AU - Ormond Filho, Alípio Gomes
AU - Nico, Marcelo Astolfi Caetano
AU - Lederman, Henrique Manoel
AU - Fayad, Laura Marie
N1 - Publisher Copyright:
© 2021 International Society for Magnetic Resonance in Medicine
PY - 2021
Y1 - 2021
N2 - Whole-body magnetic resonance imaging (WB-MRI) has gained importance in the field of musculoskeletal oncology over the last decades, consisting in a one-stop imaging method that allows a wide coverage assessment of both bone and soft tissue involvement. WB-MRI is valuable for diagnosis, staging, and follow-up in many oncologic diseases and is especially advantageous for the pediatric population since it avoids redundant examinations and exposure to ionizing radiation in patients who often undergo long-term surveillance. Its clinical application has been studied in many pediatric neoplasms, such as cancer predisposition syndromes, Langerhans cell histiocytosis, lymphoma, sarcomas, and neuroblastoma. The addition of diffusion-weighted sequences allows functional evaluation of neoplastic lesions, which is helpful in the assessment of viable tumor and response to treatment after neoadjuvant or adjuvant therapy. WB-MRI is an excellent alternative to fluorodeoxyglucose-positron emission tomography/computed tomography in oncologic children, with comparable accuracy and the convenience of being radiation-free, fast to perform, and available at a similar cost. The development of new techniques and protocols makes WB-MRI increasingly faster, safer, and more accessible, and it is important for referring physicians and radiologists to recognize the role of this imaging method in pediatric oncology. Level of Evidence: 4. Technical Efficacy Stage: 2.
AB - Whole-body magnetic resonance imaging (WB-MRI) has gained importance in the field of musculoskeletal oncology over the last decades, consisting in a one-stop imaging method that allows a wide coverage assessment of both bone and soft tissue involvement. WB-MRI is valuable for diagnosis, staging, and follow-up in many oncologic diseases and is especially advantageous for the pediatric population since it avoids redundant examinations and exposure to ionizing radiation in patients who often undergo long-term surveillance. Its clinical application has been studied in many pediatric neoplasms, such as cancer predisposition syndromes, Langerhans cell histiocytosis, lymphoma, sarcomas, and neuroblastoma. The addition of diffusion-weighted sequences allows functional evaluation of neoplastic lesions, which is helpful in the assessment of viable tumor and response to treatment after neoadjuvant or adjuvant therapy. WB-MRI is an excellent alternative to fluorodeoxyglucose-positron emission tomography/computed tomography in oncologic children, with comparable accuracy and the convenience of being radiation-free, fast to perform, and available at a similar cost. The development of new techniques and protocols makes WB-MRI increasingly faster, safer, and more accessible, and it is important for referring physicians and radiologists to recognize the role of this imaging method in pediatric oncology. Level of Evidence: 4. Technical Efficacy Stage: 2.
KW - magnetic resonance imaging
KW - musculoskeletal imaging
KW - pediatric oncology
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U2 - 10.1002/jmri.27787
DO - 10.1002/jmri.27787
M3 - Review article
C2 - 34145692
AN - SCOPUS:85108227953
SN - 1053-1807
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
ER -