Abstract
Tumor immune escape is a critical trait of cancer but the mechanisms involved have yet to fully emerge. One recent study has shown that tumor cells can escape T-cell immunity by overexpressing the endothelial cell adhesion molecule vascular cell adhesion molecule-1 (VCAM-1), which normally mediates leukocyte extravasion to sites of tissue inflammation. Renal cell carcinoma (RCC) was identified as one tumor type where VCAM-1 is commonly highly overexpressed. Together, our findings suggest that RCCs might exploit VCAM-1 overexpression for immune escape.
Original language | English (US) |
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Pages (from-to) | 6003-6006 |
Number of pages | 4 |
Journal | Cancer Research |
Volume | 67 |
Issue number | 13 |
DOIs | |
State | Published - Jul 1 2007 |
ASJC Scopus subject areas
- Oncology
- Cancer Research