The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders

Roy G. Cutler, Simonetta Camandola, Kelli F. Malott, Maria A. Edelhauser, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

High uric acid (UA) levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e.g. SOD). However, the clinical usefulness of UA is limited by its’ low water solubility and propensity to form inflammatory crystals at hyperuricemic levels. This review focuses on the role of UA in neuroprotection, as well as potential strategies aimed at increasing UA levels in the soluble range, and the potential therapeutic use of more water-soluble methyl-UA derivatives from the natural catabolic end-products of dietary caffeine, theophylline, and theobromine.

Original languageEnglish (US)
Pages (from-to)2233-2238
Number of pages6
JournalCurrent Topics in Medicinal Chemistry
Volume15
Issue number21
StatePublished - Aug 1 2015

Keywords

  • Aging
  • Antioxidant
  • Caffeine
  • Neurodegeneration
  • Theobromine
  • Urate Oxidase
  • Uric acid

ASJC Scopus subject areas

  • Drug Discovery

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  • Cite this

    Cutler, R. G., Camandola, S., Malott, K. F., Edelhauser, M. A., & Mattson, M. P. (2015). The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. Current Topics in Medicinal Chemistry, 15(21), 2233-2238.