The role of troponin abnormalities as a cause for stunned myocardium

Jennifer E. Van Eyk; Anne M. Murphy

doi:10.1097/00019501-200108000-00002

The role of troponin abnormalities as a cause for stunned myocardium

Jennifer E. Van Eyk, Anne M. Murphy

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Myocardial stunning is a form of ischemic injury, which occurs with transient ischemia followed by re-establishment of flow, and which results in reversible cardiac dysfunction. There is evidence that the molecular defect in stunning is at the level of the contractile apparatus. Selective proteolysis of the myofilament protein, troponin I, appears to underlie the phenotype of stunning in some models, but other myofilament protein modifications may also have a role.

Original language	English (US)
Pages (from-to)	343-347
Number of pages	5
Journal	Coronary artery disease
Volume	12
Issue number	5
DOIs	https://doi.org/10.1097/00019501-200108000-00002
State	Published - 2001
Externally published	Yes

Keywords

Cardiac ischemia
Myocardial stunning
Myofilaments
Proteomics
Troponin

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1097/00019501-200108000-00002

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AU - Murphy, Anne M.

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AB - Myocardial stunning is a form of ischemic injury, which occurs with transient ischemia followed by re-establishment of flow, and which results in reversible cardiac dysfunction. There is evidence that the molecular defect in stunning is at the level of the contractile apparatus. Selective proteolysis of the myofilament protein, troponin I, appears to underlie the phenotype of stunning in some models, but other myofilament protein modifications may also have a role.

KW - Cardiac ischemia

KW - Myocardial stunning

KW - Myofilaments

KW - Proteomics

KW - Troponin

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The role of troponin abnormalities as a cause for stunned myocardium

Abstract

Keywords

ASJC Scopus subject areas

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