The role of troponin abnormalities as a cause for stunned myocardium

Jennifer Van Eyk, Anne M. Murphy

Research output: Contribution to journalReview article

Abstract

Myocardial stunning is a form of ischemic injury, which occurs with transient ischemia followed by re-establishment of flow, and which results in reversible cardiac dysfunction. There is evidence that the molecular defect in stunning is at the level of the contractile apparatus. Selective proteolysis of the myofilament protein, troponin I, appears to underlie the phenotype of stunning in some models, but other myofilament protein modifications may also have a role.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalCoronary artery disease
Volume12
Issue number5
DOIs
StatePublished - Jul 31 2001

Keywords

  • Cardiac ischemia
  • Myocardial stunning
  • Myofilaments
  • Proteomics
  • Troponin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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