The role of the thalamus and basal ganglia in parkinsonian tremor

S. Hua, S. G. Reich, A. T. Zirh, V. Perry, P. M. Dougherty, Frederick Lenz

Research output: Contribution to journalArticle

Abstract

The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor-related activity characterized, respectively, by calcium spike-associated bursts and by maximal tremor-related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross-correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. Therefore, thalamic spike train activity is most consistent with parkinsonian tremor being mediated by peripheral inputs involved in either an unstable reflex loop or sensory modulation of a central oscillator.

Original languageEnglish (US)
Pages (from-to)40-42
Number of pages3
JournalMovement disorders : official journal of the Movement Disorder Society
Volume13
Issue numberSUPPL. 3
StatePublished - 1998

Fingerprint

Tremor
Basal Ganglia
Thalamus
Sensory Feedback
Globus Pallidus
Calcium Signaling
Reflex
Central Nervous System

Keywords

  • Basal ganglia
  • Feedback processes
  • Neuronal oscillators
  • Parkinson's disease
  • Thalamus
  • Tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The role of the thalamus and basal ganglia in parkinsonian tremor. / Hua, S.; Reich, S. G.; Zirh, A. T.; Perry, V.; Dougherty, P. M.; Lenz, Frederick.

In: Movement disorders : official journal of the Movement Disorder Society, Vol. 13, No. SUPPL. 3, 1998, p. 40-42.

Research output: Contribution to journalArticle

Hua, S, Reich, SG, Zirh, AT, Perry, V, Dougherty, PM & Lenz, F 1998, 'The role of the thalamus and basal ganglia in parkinsonian tremor', Movement disorders : official journal of the Movement Disorder Society, vol. 13, no. SUPPL. 3, pp. 40-42.
Hua, S. ; Reich, S. G. ; Zirh, A. T. ; Perry, V. ; Dougherty, P. M. ; Lenz, Frederick. / The role of the thalamus and basal ganglia in parkinsonian tremor. In: Movement disorders : official journal of the Movement Disorder Society. 1998 ; Vol. 13, No. SUPPL. 3. pp. 40-42.
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