The Role of the Sinonasal Epithelium in Allergic Rhinitis

Research output: Contribution to journalReview articlepeer-review

Abstract

The sinonasal epithelial barrier is comprised of tight and adherens junction proteins. Disruption of epithelial barrier function has been hypothesized to contribute to allergic disease such as allergic rhinitis through increased passage of antigens and exposure of underlying tissue to these stimuli. Several mechanisms of sinonasal epithelial barrier disruption include antigen proteolytic activity, inflammatory cytokine-mediated tight junction breakdown, or exacerbation from environmental stimuli. Mechanisms of sinonasal epithelial barrier stabilization include corticosteroids and nuclear erythroid 2-related factor 2 (Nrf2) cytoprotective pathway activation. Additional studies will aid in determining the contribution of epithelial barrier function in allergic rhinitis pathophysiology and treatment.

Original languageEnglish (US)
Pages (from-to)1043-1050
Number of pages8
JournalOtolaryngologic Clinics of North America
Volume50
Issue number6
DOIs
StatePublished - Dec 2017

Keywords

  • Allergic rhinitis
  • Epithelial permeability
  • House dust mite
  • Sinonasal barrier dysfunction
  • Tight junctions

ASJC Scopus subject areas

  • Otorhinolaryngology

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