The Role of the Sinonasal Epithelium in Allergic Rhinitis

Research output: Contribution to journalArticle

Abstract

The sinonasal epithelial barrier is comprised of tight and adherens junction proteins. Disruption of epithelial barrier function has been hypothesized to contribute to allergic disease such as allergic rhinitis through increased passage of antigens and exposure of underlying tissue to these stimuli. Several mechanisms of sinonasal epithelial barrier disruption include antigen proteolytic activity, inflammatory cytokine-mediated tight junction breakdown, or exacerbation from environmental stimuli. Mechanisms of sinonasal epithelial barrier stabilization include corticosteroids and nuclear erythroid 2-related factor 2 (Nrf2) cytoprotective pathway activation. Additional studies will aid in determining the contribution of epithelial barrier function in allergic rhinitis pathophysiology and treatment.

Original languageEnglish (US)
JournalOtolaryngologic Clinics of North America
DOIs
StateAccepted/In press - 2017

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Epithelium
Tight Junction Proteins
Adherens Junctions
Antigens
Tight Junctions
Adrenal Cortex Hormones
Cytokines
Allergic Rhinitis

Keywords

  • Allergic rhinitis
  • Epithelial permeability
  • House dust mite
  • Sinonasal barrier dysfunction
  • Tight junctions

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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title = "The Role of the Sinonasal Epithelium in Allergic Rhinitis",
abstract = "The sinonasal epithelial barrier is comprised of tight and adherens junction proteins. Disruption of epithelial barrier function has been hypothesized to contribute to allergic disease such as allergic rhinitis through increased passage of antigens and exposure of underlying tissue to these stimuli. Several mechanisms of sinonasal epithelial barrier disruption include antigen proteolytic activity, inflammatory cytokine-mediated tight junction breakdown, or exacerbation from environmental stimuli. Mechanisms of sinonasal epithelial barrier stabilization include corticosteroids and nuclear erythroid 2-related factor 2 (Nrf2) cytoprotective pathway activation. Additional studies will aid in determining the contribution of epithelial barrier function in allergic rhinitis pathophysiology and treatment.",
keywords = "Allergic rhinitis, Epithelial permeability, House dust mite, Sinonasal barrier dysfunction, Tight junctions",
author = "Nyall London and Murugappan Ramanathan",
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AU - Ramanathan, Murugappan

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AB - The sinonasal epithelial barrier is comprised of tight and adherens junction proteins. Disruption of epithelial barrier function has been hypothesized to contribute to allergic disease such as allergic rhinitis through increased passage of antigens and exposure of underlying tissue to these stimuli. Several mechanisms of sinonasal epithelial barrier disruption include antigen proteolytic activity, inflammatory cytokine-mediated tight junction breakdown, or exacerbation from environmental stimuli. Mechanisms of sinonasal epithelial barrier stabilization include corticosteroids and nuclear erythroid 2-related factor 2 (Nrf2) cytoprotective pathway activation. Additional studies will aid in determining the contribution of epithelial barrier function in allergic rhinitis pathophysiology and treatment.

KW - Allergic rhinitis

KW - Epithelial permeability

KW - House dust mite

KW - Sinonasal barrier dysfunction

KW - Tight junctions

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