TY - JOUR
T1 - The role of the phospholipid sphingomyelin in heart disease
AU - Chatterjee, Subroto
AU - Kolmakova, Antonina
AU - Miller, Michael
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/3
Y1 - 2006/3
N2 - Sphingomyelin (SM) is an integral component of mammalian cell membranes and nerves. However, the inability to catabolize SM may lead to its accumulation in various tissues and organs, resulting in pathological disorders such as Niemann Pick disease. Elevated levels of SM have also been identified as an independent risk factor for coronary heart disease. During the past two decades, data have emerged that support an important role for metabolites of SM, such as ceramide and sphingosine-1-phosphate, in the regulation of phenotypic changes such as cell proliferation, cell-cycle arrest, apoptosis and angiogenesis. Further studies of the molecular and pathobiological basis of these phospholipids may facilitate advances in the discovery of drugs with which to mitigate diseases that may result from an elevation in SM and its metabolites.
AB - Sphingomyelin (SM) is an integral component of mammalian cell membranes and nerves. However, the inability to catabolize SM may lead to its accumulation in various tissues and organs, resulting in pathological disorders such as Niemann Pick disease. Elevated levels of SM have also been identified as an independent risk factor for coronary heart disease. During the past two decades, data have emerged that support an important role for metabolites of SM, such as ceramide and sphingosine-1-phosphate, in the regulation of phenotypic changes such as cell proliferation, cell-cycle arrest, apoptosis and angiogenesis. Further studies of the molecular and pathobiological basis of these phospholipids may facilitate advances in the discovery of drugs with which to mitigate diseases that may result from an elevation in SM and its metabolites.
KW - Ceramide
KW - Cholesterol
KW - Coronary heart disease
KW - Sphingomyelinase
KW - Sphingosine 1-phosphate
UR - http://www.scopus.com/inward/record.url?scp=33644950983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644950983&partnerID=8YFLogxK
M3 - Review article
C2 - 16555682
AN - SCOPUS:33644950983
VL - 7
SP - 219
EP - 228
JO - Current Opinion in Investigational Drugs
JF - Current Opinion in Investigational Drugs
SN - 1472-4472
IS - 3
ER -