The role of the nuclear matrix in cancer chemotherapy

H. J. Muenchen, K. J. Pienta

Research output: Contribution to journalReview articlepeer-review

Abstract

The nuclear matrix is the site of many nuclear functions including transcription, replication, formation of chromatin loops, and control of DNA supercoiling. It contains various structural and functional components that represent targets for antineoplastic agents. Antimetabolites and topoisomerase II inhibitors interact specifically with matrix-associated enzymes, DNA primase, and DNA topoisomerase II, respectively. Alkylating agents and ionizing radiation interact with nuclear matrix proteins and matrix-associated DNA. Many nuclear functions, including multidrug resistance, and others which lead to cell death, have been shown to be compromised when these anticancer agents interact with the nuclear matrix.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalCritical Reviews in Eukaryotic Gene Expression
Volume9
Issue number3-4
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Alkylating agents
  • Anticancer agents
  • Antimetabolites
  • Ionizing radiation
  • Topoisomerase I
  • Topoisomerase II

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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