The role of the noradrenergic system on the formation of synapses in the visual cortex of the rat

John G. Parnavelas, Mary E. Blue

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of norepinephrine on cortical synaptogenesis was examined in the visual cortex of rats whose noradrenergic afferents were selectively eliminated with 6-hydroxydopamine. Extensive synapse counts showed a significantly higher synaptic density in the cortex of the 6-hydroxydopamine-treated rats compared to control littermates. This increase was most pronounced during the first week of postnatal life. The results suggest an inhibitory role for norepinephrine in synaptogenesis.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalDevelopmental Brain Research
Volume3
Issue number1
DOIs
StatePublished - Jan 1982
Externally publishedYes

Keywords

  • 6-hydroxydopamine
  • development
  • norepinephrine
  • rat
  • synaptogenesis
  • visual cortex

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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