Abstract
The influence of norepinephrine on cortical synaptogenesis was examined in the visual cortex of rats whose noradrenergic afferents were selectively eliminated with 6-hydroxydopamine. Extensive synapse counts showed a significantly higher synaptic density in the cortex of the 6-hydroxydopamine-treated rats compared to control littermates. This increase was most pronounced during the first week of postnatal life. The results suggest an inhibitory role for norepinephrine in synaptogenesis.
Original language | English (US) |
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Pages (from-to) | 140-144 |
Number of pages | 5 |
Journal | Developmental Brain Research |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1982 |
Externally published | Yes |
Keywords
- 6-hydroxydopamine
- development
- norepinephrine
- rat
- synaptogenesis
- visual cortex
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology