The role of the noradrenergic system on the formation of synapses in the visual cortex of the rat

John G. Parnavelas; Mary E. Blue

doi:10.1016/0165-3806(82)90082-7

The role of the noradrenergic system on the formation of synapses in the visual cortex of the rat

John G. Parnavelas, Mary E. Blue

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of norepinephrine on cortical synaptogenesis was examined in the visual cortex of rats whose noradrenergic afferents were selectively eliminated with 6-hydroxydopamine. Extensive synapse counts showed a significantly higher synaptic density in the cortex of the 6-hydroxydopamine-treated rats compared to control littermates. This increase was most pronounced during the first week of postnatal life. The results suggest an inhibitory role for norepinephrine in synaptogenesis.

Original language	English (US)
Pages (from-to)	140-144
Number of pages	5
Journal	Developmental Brain Research
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(82)90082-7
State	Published - Jan 1982
Externally published	Yes

Keywords

6-hydroxydopamine
development
norepinephrine
rat
synaptogenesis
visual cortex

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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title = "The role of the noradrenergic system on the formation of synapses in the visual cortex of the rat",

abstract = "The influence of norepinephrine on cortical synaptogenesis was examined in the visual cortex of rats whose noradrenergic afferents were selectively eliminated with 6-hydroxydopamine. Extensive synapse counts showed a significantly higher synaptic density in the cortex of the 6-hydroxydopamine-treated rats compared to control littermates. This increase was most pronounced during the first week of postnatal life. The results suggest an inhibitory role for norepinephrine in synaptogenesis.",

keywords = "6-hydroxydopamine, development, norepinephrine, rat, synaptogenesis, visual cortex",

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note = "Funding Information: This work was supported by USPHS Grant EY02964 and by the Alfred P. Sloan Foundation. We wish to thank Dr. John K. McDonald for reading the manuscript and Ms. Sharon Edmunds for technical help.",

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AU - Blue, Mary E.

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