The role of the mouse model in the evaluation of new antituberculosis drugs

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

For the first time in 4 decades, new agents with novel mechanisms of action have entered clinical trials designed to evaluate their potential to improve the treatment of tuberculosis. Much of the optimism surrounding these new drugs comes from promising results observed in animal models. Moreover, selection of the most promising combinations of new and existing drugs to form entirely novel regimens for future trials will also rely on information from animal studies. This review describes the historical track record of experimental animal chemotherapy models, their potential pitfalls and recent efforts to improve their utility. Although the mouse model is featured, the role of other animal models is also briefly considered.

Original languageEnglish (US)
Title of host publicationAntituberculosis Chemotherapy
PublisherS. Karger AG
Pages145-152
Number of pages8
Volume10
ISBN (Electronic)9783805596282
ISBN (Print)9783805596275
DOIs
StatePublished - Sep 7 2011

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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