The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis

Regan M. Memmott, Phillip A. Dennis

Research output: Contribution to journalReview article

Abstract

Lung cancer is the leading cause of cancer-related death in the United States, and 85 to 90% of lung cancer cases are associated with tobacco use. Tobacco components promote lung tumorigenesis through genotoxic effects, as well as through biochemical modulation of signaling pathways such as the Akt/mammalian target of rapamycin (mTOR) pathway that regulates cell proliferation and survival. This review will describe cell surface receptors and other upstream components required for tobacco carcinogen - induced activation of Akt and mTOR. Preclinical studies show that inhibitors of the Akt/mTOR pathway inhibit tumor formation in mouse models of carcinogen-induced lung tumorigenesis. Some of these inhibitors will be highlighted, and their clinical potential for the treatment and prevention of lung cancer will be discussed.

Original languageEnglish (US)
Pages (from-to)4-10
Number of pages7
JournalClinical Cancer Research
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2010

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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