The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis

Yuquan Xie, Ruizhen Chen, Xian Zhang, Ping Chen, Xujie Liu, Yeqing Xie, Yong Yu, Yingzhen Yang, Yunzeng Zou, Junbo Ge, Haozhu Chen

Research output: Contribution to journalArticlepeer-review

Abstract

IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalVirology
Volume421
Issue number1
DOIs
StatePublished - Dec 5 2011

Keywords

  • Coxsackievirus B
  • Th17 cell
  • Treg cell
  • Viral myocarditis

ASJC Scopus subject areas

  • Virology

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