The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis

Yuquan Xie; Ruizhen Chen; Xian Zhang; Ping Chen; Xujie Liu; Yeqing Xie; Yong Yu; Yingzhen Yang; Yunzeng Zou; Junbo Ge; Haozhu Chen

doi:10.1016/j.virol.2011.09.006

The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis

Yuquan Xie, Ruizhen Chen, Xian Zhang, Ping Chen, Xujie Liu, Yeqing Xie, Yong Yu, Yingzhen Yang, Yunzeng Zou, Junbo Ge, Haozhu Chen

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC.

Original language	English (US)
Pages (from-to)	78-84
Number of pages	7
Journal	Virology
Volume	421
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2011.09.006
State	Published - Dec 5 2011
Externally published	Yes

Keywords

Coxsackievirus B
Th17 cell
Treg cell
Viral myocarditis

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2011.09.006

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title = "The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis",

abstract = "IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC.",

keywords = "Coxsackievirus B, Th17 cell, Treg cell, Viral myocarditis",

author = "Yuquan Xie and Ruizhen Chen and Xian Zhang and Ping Chen and Xujie Liu and Yeqing Xie and Yong Yu and Yingzhen Yang and Yunzeng Zou and Junbo Ge and Haozhu Chen",

note = "Funding Information: This project was supported by grants from the National Natural Science Foundation of China (Nos. 30772021 , 31070786 ), Research Fund for the Doctoral Program of Higher Education of China ( 20090071110076 ) and PhD Program Scholarship Fund of Fudan University .",

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AU - Xie, Yuquan

AU - Chen, Ruizhen

AU - Zhang, Xian

AU - Chen, Ping

AU - Liu, Xujie

AU - Xie, Yeqing

AU - Yu, Yong

AU - Yang, Yingzhen

AU - Zou, Yunzeng

AU - Ge, Junbo

AU - Chen, Haozhu

N1 - Funding Information: This project was supported by grants from the National Natural Science Foundation of China (Nos. 30772021 , 31070786 ), Research Fund for the Doctoral Program of Higher Education of China ( 20090071110076 ) and PhD Program Scholarship Fund of Fudan University .

PY - 2011/12/5

Y1 - 2011/12/5

N2 - IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC.

AB - IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC.

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KW - Treg cell

KW - Viral myocarditis

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The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis

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Keywords

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