The role of telomeres and telomerase in endocrine tumors.

Guennadi Kouniavsky, Martha A. Zeiger

Research output: Contribution to journalReview articlepeer-review

Abstract

The enzyme, telomerase, is a reverse transcriptase that synthesizes the telomeric ends of linear chromosomes and compensate for the shortened telomere, thereby immortalizing the cell. It is present at the blastocyst stage of embryological development, low or undetectable in most somatic cells, and activated in cancer. Because of its strong association with cancer cell immortalization and proliferation, numerous attempts have been made to capitalize on its diagnostic, prognostic, and therapeutic potential. Herein we discuss the role of telomerase in normal, benign, and cancerous endocrine tissues.

Original languageEnglish (US)
Pages (from-to)340-347
Number of pages8
JournalDiscovery Medicine
Volume10
Issue number53
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Medicine(all)

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