The role of telomere biology in bone marrow failure and other disorders

Sharon A. Savage; Blanche P. Alter

doi:10.1016/j.mad.2007.11.002

The role of telomere biology in bone marrow failure and other disorders

Sharon A. Savage, Blanche P. Alter

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Telomeres, consisting of nucleotide repeats and a protein complex at chromosome ends, are essential in maintaining chromosomal integrity. Dyskeratosis congenita (DC) is the inherited bone marrow failure syndrome (IBMFS) that epitomizes the effects of abnormal telomere biology. Patients with DC have extremely short telomere lengths (

Original language	English (US)
Pages (from-to)	35-47
Number of pages	13
Journal	Mechanisms of Ageing and Development
Volume	129
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mad.2007.11.002
State	Published - Jan 2008
Externally published	Yes

Keywords

Aplastic anemia
Bone marrow failure
Dyskeratosis congenita
Pulmonary fibrosis
Telomere

ASJC Scopus subject areas

Aging
Biochemistry
Developmental Biology
Developmental Neuroscience

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10.1016/j.mad.2007.11.002

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title = "The role of telomere biology in bone marrow failure and other disorders",

abstract = "Telomeres, consisting of nucleotide repeats and a protein complex at chromosome ends, are essential in maintaining chromosomal integrity. Dyskeratosis congenita (DC) is the inherited bone marrow failure syndrome (IBMFS) that epitomizes the effects of abnormal telomere biology. Patients with DC have extremely short telomere lengths (",

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AU - Alter, Blanche P.

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AB - Telomeres, consisting of nucleotide repeats and a protein complex at chromosome ends, are essential in maintaining chromosomal integrity. Dyskeratosis congenita (DC) is the inherited bone marrow failure syndrome (IBMFS) that epitomizes the effects of abnormal telomere biology. Patients with DC have extremely short telomere lengths (

KW - Aplastic anemia

KW - Bone marrow failure

KW - Dyskeratosis congenita

KW - Pulmonary fibrosis

KW - Telomere

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The role of telomere biology in bone marrow failure and other disorders

Abstract

Keywords

ASJC Scopus subject areas

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