The role of telomere biology in bone marrow failure and other disorders

Sharon A. Savage, Blanche P. Alter

Research output: Contribution to journalArticlepeer-review

Abstract

Telomeres, consisting of nucleotide repeats and a protein complex at chromosome ends, are essential in maintaining chromosomal integrity. Dyskeratosis congenita (DC) is the inherited bone marrow failure syndrome (IBMFS) that epitomizes the effects of abnormal telomere biology. Patients with DC have extremely short telomere lengths (

Original languageEnglish (US)
Pages (from-to)35-47
Number of pages13
JournalMechanisms of Ageing and Development
Volume129
Issue number1-2
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • Aplastic anemia
  • Bone marrow failure
  • Dyskeratosis congenita
  • Pulmonary fibrosis
  • Telomere

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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