Abstract
Chronic inflammation plays a critical role in the development of obesity-associated metabolic disorders such as insulin resistance. Obesity alters the microenvironment of adipose tissue and the intestines from anti-inflammatory to pro-inflammatory, which promotes low grade systemic inflammation and insulin resistance in obese mice. Various T cell subsets either help maintain metabolic homeostasis in healthy states or contribute to obesity-associated metabolic syndromes. In this review, we will discuss the T cell subsets that reside in adipose tissue and intestines and their role in the development of obesity-induced systemic inflammation.
Original language | English (US) |
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Article number | e13 |
Journal | Immune Network |
Volume | 22 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2022 |
Keywords
- Insulin resistance
- Metabolic diseases
- Obese mice
- Obesity-associated inflammation
- T cells
ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy
- Immunology