TY - JOUR
T1 - The role of sexual behavior in head and neck cancer
T2 - Implications for prevention and therapy
AU - Rettig, Eleni
AU - Kiess, Ana Ponce
AU - Fakhry, Carole
N1 - Publisher Copyright:
© 2015 Informa UK Ltd.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - HPV-positive oropharyngeal squamous cell carcinoma (HPV-OSCC) is associated with oral sexual behaviors. The sharp rise in incidence of HPV-OSCC in the USA has been attributed to changes in sexual norms over the past five decades, with lower age at sexual debut and higher numbers of sexual partners per individual. In addition, variations in HPV-OSCC prevalence by race, age cohort and gender may be attributable to differences in oral sexual behaviors among these groups. Oral HPV infection is the putative precursor to HPV-OSCC. Risk factors for oral HPV incidence, prevalence, clearance and persistence are crucial to understanding how, and in whom, oral HPV infection progresses to malignancy. Future investigation should focus on elucidating the natural history of oral HPV infection persistence and malignant transformation, developing effective screening tools and exploring opportunities for prevention such as vaccination and public health education.
AB - HPV-positive oropharyngeal squamous cell carcinoma (HPV-OSCC) is associated with oral sexual behaviors. The sharp rise in incidence of HPV-OSCC in the USA has been attributed to changes in sexual norms over the past five decades, with lower age at sexual debut and higher numbers of sexual partners per individual. In addition, variations in HPV-OSCC prevalence by race, age cohort and gender may be attributable to differences in oral sexual behaviors among these groups. Oral HPV infection is the putative precursor to HPV-OSCC. Risk factors for oral HPV incidence, prevalence, clearance and persistence are crucial to understanding how, and in whom, oral HPV infection progresses to malignancy. Future investigation should focus on elucidating the natural history of oral HPV infection persistence and malignant transformation, developing effective screening tools and exploring opportunities for prevention such as vaccination and public health education.
KW - head and neck neoplasms
KW - health education
KW - human papillomavirus
KW - human papillomavirus vaccines
KW - oral sex
KW - oropharyngeal neoplasms
KW - sexual behavior
KW - sexually transmitted diseases
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U2 - 10.1586/14737140.2015.957189
DO - 10.1586/14737140.2015.957189
M3 - Review article
C2 - 25193346
AN - SCOPUS:84919794056
SN - 1473-7140
VL - 15
SP - 35
EP - 49
JO - Expert Review of Anticancer Therapy
JF - Expert Review of Anticancer Therapy
IS - 1
ER -