The role of serotonin in schizophrenia: an overview of the nomenclature, distribution and alterations of serotonin receptors in the central nervous system

Donald C. Ohuoha, Thomas Hyde, Joel Kleinman

Research output: Contribution to journalArticle

Abstract

Serotonin is a neurotransmitter that is widely distributed throughout the central nervous system. The role of serotonin in schizophrenia is still unclear. Postmortem studies of serotonin receptor subtypes in schizophrenia have been inconclusive for the most part. The most promising findings involve a reduction in 5-HT2 receptors and 5-HT reuptake sites in the prefrontal cortex of schizophrenic patients. In this paper we review the function, distribution and pharmacological characteristics of serotonin receptors. Postmortem studies are also reviewed, focusing upon the role of these receptors in schizophrenia.

Original languageEnglish (US)
JournalPsychopharmacology
Volume112
Issue number1 Supplement
DOIs
StatePublished - Mar 1993
Externally publishedYes

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Serotonin Receptors
Terminology
Serotonin
Schizophrenia
Central Nervous System
Prefrontal Cortex
Neurotransmitter Agents
Pharmacology

Keywords

  • 5-HT receptors
  • Classification
  • Nomenclature
  • Postmortem studies
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology

Cite this

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