The role of regulatory T-cells in glioma immunology

Yinn Cher Ooi, Patrick Tran, Nolan Ung, Kimberly Thill, Andy Trang, Brendan M. Fong, Daniel T. Nagasawa, Michael Lim, Isaac Yang

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite recent advances in treatment, the prognosis for glioblastoma multiforme (GBM) remains poor. The lack of response to treatment in GBM patients may be attributed to the immunosuppressed microenvironment that is characteristic of invasive glioma. Regulatory T-cells (Tregs) are immunosuppressive T-cells that normally prevent autoimmunity when the human immune response is evoked; however, there have been strong correlations between glioma-induced immunosuppression and Tregs. In fact, induction of Treg activity has been correlated with glioma development in both murine models and patients. While the exact mechanisms by which regulatory T-cells function require further elucidation, various cytokines such as interleukin-10 (IL-10) and transforming growth factor-β (TFG-β) have been implicated in these processes and are currently under investigation. In addition, hypoxia is characteristic of tumor development and is also correlated with downstream induction of Tregs. Due to the poor prognosis associated with immunosuppression in glioma patients, Tregs remain a promising area for immunotherapeutic research.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalClinical Neurology and Neurosurgery
Volume119
DOIs
StatePublished - Apr 2014

Keywords

  • Gliomas
  • Immunology
  • Regulatory T-cells

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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