The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors

Yefei Han, Jun Lai, Patricia Barditch-Crovo, Joel E. Gallant, Thomas M. Williams, Robert F. Siliciano, Joel N. Blankson

Research output: Contribution to journalArticlepeer-review

Abstract

Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene. These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
JournalAIDS
Volume22
Issue number4
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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