The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors

Yefei Han; Jun Lai; Patricia Barditch-Crovo; Joel E. Gallant; Thomas M. Williams; Robert F. Siliciano; Joel N. Blankson

doi:10.1097/QAD.0b013e3282f470e4

The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors

Yefei Han, Jun Lai, Patricia Barditch-Crovo, Joel E. Gallant, Thomas M. Williams, Robert F. Siliciano, Joel N. Blankson

School of Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene. These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors.

Original language	English (US)
Pages (from-to)	541-544
Number of pages	4
Journal	AIDS
Volume	22
Issue number	4
DOIs	https://doi.org/10.1097/QAD.0b013e3282f470e4
State	Published - Feb 2008

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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abstract = "Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene. These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors.",

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AU - Gallant, Joel E.

AU - Williams, Thomas M.

AU - Siliciano, Robert F.

AU - Blankson, Joel N.

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AB - Elite suppressors (ES) are untreated HIV-1-infected patients who maintain undetectable viral loads. A recent whole-genome analysis identified two independent polymorphisms associated with low viral loads in untreated HIV-1 infection. We screened 16 ES; none were positive for the protective HLA complex 5 gene polymorphism, and only four were positive for the protective polymorphism associated with the HLA-C gene. These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors.

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The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors

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