The role of platelet receptors and adhesion molecules in coronary artery disease

Waiel M. Samara, Paul A. Gurbel

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Platelets play a significant role in coronary artery disease through interactions with each other and with other cell types. These interactions are mediated by certain receptors on the surface of platelets and other cells which can lead to intra-coronary thrombus formation and occlusion that may result in acute coronary syndromes. The important roles of the currently available anti-platelet therapies have been well established in many clinical outcome trials in cardiovascular patients. An understanding of these different interactions provides the clinician with a background that supports the clinical importance of currently available anti-platelet therapies. Moreover, knowledge of the mechanisms of cellular crosstalk will lead to important advances in the development of better antithrombotic therapies.

Original languageEnglish (US)
Pages (from-to)65-79
Number of pages15
JournalCoronary artery disease
Issue number1
StatePublished - Feb 1 2003


  • Acute coronary syndrome
  • Platelet activation
  • Platelet adhesion
  • Platelet aggregation
  • Platelet receptors
  • Platelet-leucocyte interactions

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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