The role of platelet function testing in risk stratification and clinical decision-making

Paul A. Gurbel; Udaya S. Tantry

doi:10.1016/j.iccl.2013.05.009

The role of platelet function testing in risk stratification and clinical decision-making

Paul A. Gurbel, Udaya S. Tantry

School of Medicine

Research output: Contribution to journal › Review article

Abstract

Clopidogrel (a widely used second-generation thienopyridine) therapy is associated with an unpredictable pharmacodynamic response whereby approximately 1 in 3 patients will have a high on-treatment platelet reactivity to adenosine diphosphate. High on-treatment platelet reactivity is an established risk factor for ischemic event occurrence in patients undergoing percutaneous coronary intervention. Platelet function testing may have a role in monitoring therapeutic efficacy when clopidogrel is the chosen agent and in safety when more potent drugs are used, especially in patients with high bleeding risk. At this time, it seems most reasonable to assess platelet function in high-risk clopidogrel-treated patients.

Original language	English (US)
Pages (from-to)	607-614
Number of pages	8
Journal	Interventional Cardiology Clinics
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.iccl.2013.05.009
State	Published - Oct 1 2013

Keywords

Bleeding
Clopidogrel
High on-treatment platelet reactivity
P2Y receptor
Percutaneous coronary intervention
Platelet function testing

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.iccl.2013.05.009

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Gurbel, P. A., & Tantry, U. S. (2013). The role of platelet function testing in risk stratification and clinical decision-making. Interventional Cardiology Clinics, 2(4), 607-614. https://doi.org/10.1016/j.iccl.2013.05.009

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