The role of pituitary gonadotropins in follicular stimulation and oocyte maturation in the human

G. S. Jones, J. E. Garcia, Z. Rosenwaks

Research output: Contribution to journalArticle


The serum estradiol (E2) values in normally ovulating infertile women stimulated first by a combination of follicle stimulating hormone fFSH) and luteinizing hormone (LH) [human menopausal gonadotropin (HMG)] and second by FSH only were similar in both stimulation cycles. The serum FSH and LH values measured in one patient were also similar. Basal LH declined by 16 hours after HMG or FSH administration. These data suggest that exogenous LH is not required for follicular maturation as measured by E2 synthesis during ovulation induction in normal women. Maturation of the oocyte, at least in some patients, also progressed normally after the administration of FSH alone, followed by human chorionic gonadotropin (HCG), as indicated by the retrieval of viable oocytes which fertilized and cleaved in all patients and the initiation of a pregnancy which progressed normally.

Original languageEnglish (US)
Pages (from-to)178-180
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number1
StatePublished - Jul 1984
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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