TY - JOUR
T1 - The role of piRNA and its potential clinical implications in cancer
AU - Assumpção, Carolina Baraúna
AU - Calcagno, Danielle Queiroz
AU - Araújo, Taíssa Maíra Thomaz
AU - Batista Dos Santos, Sidney Emmanuel
AU - Ribeiro Dos Santos, Ândrea Kely Campos
AU - Riggins, Gregory Joseph
AU - Burbano, Rommel Rodriguez
AU - Assumpção, Paulo Pimentel
N1 - Publisher Copyright:
© 2014 PP Assumpção.
PY - 2015/9
Y1 - 2015/9
N2 - Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules has yet been elucidated. A brief overview of piRNA biogenesis and their potential roles as part of an epigenetic network that is possibly involved in cancer is provided. Moreover, potential strategies based on the use of piRNAs and PIWI proteins as diagnostic and prognostic biomarkers as well as for cancer therapeutics are discussed.
AB - Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules has yet been elucidated. A brief overview of piRNA biogenesis and their potential roles as part of an epigenetic network that is possibly involved in cancer is provided. Moreover, potential strategies based on the use of piRNAs and PIWI proteins as diagnostic and prognostic biomarkers as well as for cancer therapeutics are discussed.
KW - PIWI
KW - cancer biomarker
KW - cancer therapy
KW - epigenetic network
KW - piRNA
UR - http://www.scopus.com/inward/record.url?scp=84939785800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939785800&partnerID=8YFLogxK
U2 - 10.2217/epi.15.37
DO - 10.2217/epi.15.37
M3 - Review article
C2 - 25929784
AN - SCOPUS:84939785800
SN - 1750-1911
VL - 7
SP - 975
EP - 984
JO - Epigenomics
JF - Epigenomics
IS - 6
ER -