The role of pentoxifylline in renal ischemic reperfusion cell injury and inflammatory reaction

Doustar Yousef, Kazemii Davuod, Nasaghi Habibolah, Zare Hossein, Safarmashaei Saeid

Research output: Contribution to journalArticle

Abstract

Ischemic/reperfusion induced cell death and inflammatory reaction (acute renal failure) is a common clinical problem associated with acute renal failure and renal transplantation. In this study the effects of pentoxifylline on the attenuation of an ischemia-reperfusion injury and inflammatory reaction were examined. Twelve adult mixed breed dogs of both sexes, weighing 10-20 kg, were chosen and then the dogs were assigned randomly into control and treatment groups (n=6).Celiotomy was performed by ventral midline incision. The left kidney was isolated, and then both the renal artery and vein were clamped. After 60 minutes of warm ischemia, the vessels were unclamped and followed by 72 hours of reperfusion, while the right kidney was removed. Blood samples were collected before ischemia and at 24, 48 and 72 hours after ischemia for determination of serum creatinine and BUN level. After 72 hours of ischemia-reperfusion tissue samples from the left kidney were taken for histopathology examination. The treatment group showed lower creatinine, BUN (P<0.001 each), cell death (P<0.05 each) and of renal inflammatory reactions than did the control group. The result of this study indicates that pentoxifylline alone might play a role in attenuation ischemia-reperfusion cell injury and reduced inflammatory reaction that may contribute to the ischemic renal damage.

Original languageEnglish (US)
Pages (from-to)1522-1526
Number of pages5
JournalAdvances in Environmental Biology
Volume5
Issue number7
StatePublished - Jun 1 2011
Externally publishedYes

Keywords

  • Apoptosis
  • Ischemic reperfusion
  • Necrosis
  • Pentoxifylline
  • Renal

ASJC Scopus subject areas

  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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