The role of parkin in familial and sporadic Parkinson's disease

Ted M. Dawson; Valina L. Dawson

doi:10.1002/mds.22798

The role of parkin in familial and sporadic Parkinson's disease

Ted M. Dawson, Valina L. Dawson

School of Medicine

Research output: Contribution to journal › Article › peer-review

217 Scopus citations

Abstract

Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society

Original language	English (US)
Pages (from-to)	S32-S39
Journal	Movement Disorders
Volume	25
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/mds.22798
State	Published - 2010

Keywords

AIMP2
FBP-1
Mitochondria
PINK1
Proteasome
Ubiquitin

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/mds.22798

Cite this

@article{6287638b512a4c83bc94b880f6ea2b66,

title = "The role of parkin in familial and sporadic Parkinson's disease",

abstract = "Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. {\textcopyright} 2010 Movement Disorder Society",

keywords = "AIMP2, FBP-1, Mitochondria, PINK1, Proteasome, Ubiquitin",

author = "Dawson, {Ted M.} and Dawson, {Valina L.}",

year = "2010",

doi = "10.1002/mds.22798",

language = "English (US)",

volume = "25",

pages = "S32--S39",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley and Sons Inc.",

number = "SUPPL. 1",

}

TY - JOUR

T1 - The role of parkin in familial and sporadic Parkinson's disease

AU - Dawson, Ted M.

AU - Dawson, Valina L.

PY - 2010

Y1 - 2010

N2 - Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society

AB - Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society

KW - AIMP2

KW - FBP-1

KW - Mitochondria

KW - PINK1

KW - Proteasome

KW - Ubiquitin

UR - http://www.scopus.com/inward/record.url?scp=77953424577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953424577&partnerID=8YFLogxK

U2 - 10.1002/mds.22798

DO - 10.1002/mds.22798

M3 - Article

C2 - 20187240

AN - SCOPUS:77953424577

SN - 0885-3185

VL - 25

SP - S32-S39

JO - Movement Disorders

JF - Movement Disorders

IS - SUPPL. 1

ER -

The role of parkin in familial and sporadic Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this