The role of parkin in familial and sporadic Parkinson's disease

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Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society

Original languageEnglish (US)
Pages (from-to)S32-S39
JournalMovement Disorders
Issue numberSUPPL. 1
StatePublished - 2010


  • AIMP2
  • FBP-1
  • Mitochondria
  • PINK1
  • Proteasome
  • Ubiquitin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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