The Role of Parallel Diffusion-Weighted Imaging and Apparent Diffusion Coefficient (ADC) Map Values for Evaluating Breast Lesions. Preliminary Results

Guangwei Jin, Ningyu An, Michael A. Jacobs, Kuncheng Li

Research output: Contribution to journalArticle

Abstract

Rationale and Objectives: To evaluate the feasibility of using diffusion-weighted imaging (DWI) with an array spatial sensitivity encoding technique (ASSET) and apparent diffusion coefficient (ADC) map values with different b values to distinguish benign and malignant breast lesions. Materials and Methods: Fifty-six female patients with 60 histologically proven breast lesions and 20 healthy volunteers underwent magnetic resonance imaging. A subset of normal volunteers (n = 7) and patients (n = 16) underwent both conventional DWI and ASSET-DWI, and the image quality between the two methods was compared. Finally, ASSET-DWI with b = 0, 600 s/mm2, and b = 0, 1000 s/mm2, were compared for their ability to distinguish benign and malignant breast lesions. Results: The ASSET-DWI method had less distortion, fewer artifacts, and a lower acquisition time than other methods. No significant difference (P > .05) was detected in ADC map values between ASSET-DWI and conventional DWI. For ASSET-DWI, the sensitivity of ADC values for malignant lesions with a threshold of less than 1.44 × 10-3 mm2/s (b = 600 s/mm2) and 1.18 × 10-3 mm2/s (b = 1000 s/mm2) was 80% and 77.5%, respectively. The specificity of both groups was 95%. Conclusion: ASSET-DWI evaluation of breast tissue offers decreased distortion, susceptibility to artifacts, and acquisition time relative to other methods. The use of ASSET-DWI is feasible with b values ranging from 600 to 1000 s/mm2 and provides increased specificity compared to other techniques. Thus, the ADC value of a breast lesion can be used to further characterize malignant lesions from benign ones.

Original languageEnglish (US)
Pages (from-to)456-463
Number of pages8
JournalAcademic radiology
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2010

Keywords

  • Diffusion-weighted imaging (DWI)
  • MRI
  • apparent diffusion coefficient (ADC) map
  • breast carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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