TY - JOUR
T1 - The Role of Parallel Diffusion-Weighted Imaging and Apparent Diffusion Coefficient (ADC) Map Values for Evaluating Breast Lesions. Preliminary Results
AU - Jin, Guangwei
AU - An, Ningyu
AU - Jacobs, Michael A.
AU - Li, Kuncheng
N1 - Funding Information:
This work was supported in part by NIH 1R01CA100184 .
PY - 2010/4
Y1 - 2010/4
N2 - Rationale and Objectives: To evaluate the feasibility of using diffusion-weighted imaging (DWI) with an array spatial sensitivity encoding technique (ASSET) and apparent diffusion coefficient (ADC) map values with different b values to distinguish benign and malignant breast lesions. Materials and Methods: Fifty-six female patients with 60 histologically proven breast lesions and 20 healthy volunteers underwent magnetic resonance imaging. A subset of normal volunteers (n = 7) and patients (n = 16) underwent both conventional DWI and ASSET-DWI, and the image quality between the two methods was compared. Finally, ASSET-DWI with b = 0, 600 s/mm2, and b = 0, 1000 s/mm2, were compared for their ability to distinguish benign and malignant breast lesions. Results: The ASSET-DWI method had less distortion, fewer artifacts, and a lower acquisition time than other methods. No significant difference (P > .05) was detected in ADC map values between ASSET-DWI and conventional DWI. For ASSET-DWI, the sensitivity of ADC values for malignant lesions with a threshold of less than 1.44 × 10-3 mm2/s (b = 600 s/mm2) and 1.18 × 10-3 mm2/s (b = 1000 s/mm2) was 80% and 77.5%, respectively. The specificity of both groups was 95%. Conclusion: ASSET-DWI evaluation of breast tissue offers decreased distortion, susceptibility to artifacts, and acquisition time relative to other methods. The use of ASSET-DWI is feasible with b values ranging from 600 to 1000 s/mm2 and provides increased specificity compared to other techniques. Thus, the ADC value of a breast lesion can be used to further characterize malignant lesions from benign ones.
AB - Rationale and Objectives: To evaluate the feasibility of using diffusion-weighted imaging (DWI) with an array spatial sensitivity encoding technique (ASSET) and apparent diffusion coefficient (ADC) map values with different b values to distinguish benign and malignant breast lesions. Materials and Methods: Fifty-six female patients with 60 histologically proven breast lesions and 20 healthy volunteers underwent magnetic resonance imaging. A subset of normal volunteers (n = 7) and patients (n = 16) underwent both conventional DWI and ASSET-DWI, and the image quality between the two methods was compared. Finally, ASSET-DWI with b = 0, 600 s/mm2, and b = 0, 1000 s/mm2, were compared for their ability to distinguish benign and malignant breast lesions. Results: The ASSET-DWI method had less distortion, fewer artifacts, and a lower acquisition time than other methods. No significant difference (P > .05) was detected in ADC map values between ASSET-DWI and conventional DWI. For ASSET-DWI, the sensitivity of ADC values for malignant lesions with a threshold of less than 1.44 × 10-3 mm2/s (b = 600 s/mm2) and 1.18 × 10-3 mm2/s (b = 1000 s/mm2) was 80% and 77.5%, respectively. The specificity of both groups was 95%. Conclusion: ASSET-DWI evaluation of breast tissue offers decreased distortion, susceptibility to artifacts, and acquisition time relative to other methods. The use of ASSET-DWI is feasible with b values ranging from 600 to 1000 s/mm2 and provides increased specificity compared to other techniques. Thus, the ADC value of a breast lesion can be used to further characterize malignant lesions from benign ones.
KW - Diffusion-weighted imaging (DWI)
KW - MRI
KW - apparent diffusion coefficient (ADC) map
KW - breast carcinoma
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U2 - 10.1016/j.acra.2009.12.004
DO - 10.1016/j.acra.2009.12.004
M3 - Article
C2 - 20207316
AN - SCOPUS:77649178042
SN - 1076-6332
VL - 17
SP - 456
EP - 463
JO - Academic radiology
JF - Academic radiology
IS - 4
ER -