TY - JOUR
T1 - The role of osteoblasts in energy homeostasis
AU - Dirckx, Naomi
AU - Moorer, Megan C.
AU - Clemens, Thomas L.
AU - Riddle, Ryan C.
N1 - Funding Information:
The authors gratefully acknowledge the work by other investigators that has not been cited in this manuscript because of space limitations. Work in the authors’ laboratories is supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (DK099134, R.C.R) and the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development (BX003724, R.C.R; BX001234, T.L.C.). T.L.C is also the recipient of a Senior Research Career Scientist Award from the Department of Veterans Affairs.
Publisher Copyright:
© 2019, Springer Nature Limited.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the skeleton. These cells work in harmony with osteoclasts, which resorb bone, in a continuous cycle that occurs throughout life. The unique function of osteoblasts requires substantial amounts of energy production, particularly during states of new bone formation and remodelling. Over the last 15 years, studies have shown that osteoblasts secrete endocrine factors that integrate the metabolic requirements of bone formation with global energy balance through the regulation of insulin production, feeding behaviour and adipose tissue metabolism. In this article, we summarize the current understanding of three osteoblast-derived metabolic hormones (osteocalcin, lipocalin and sclerostin) and the clinical evidence that suggests the relevance of these pathways in humans, while also discussing the necessity of specific energy substrates (glucose, fatty acids and amino acids) to fuel bone formation and promote osteoblast differentiation.
AB - Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the skeleton. These cells work in harmony with osteoclasts, which resorb bone, in a continuous cycle that occurs throughout life. The unique function of osteoblasts requires substantial amounts of energy production, particularly during states of new bone formation and remodelling. Over the last 15 years, studies have shown that osteoblasts secrete endocrine factors that integrate the metabolic requirements of bone formation with global energy balance through the regulation of insulin production, feeding behaviour and adipose tissue metabolism. In this article, we summarize the current understanding of three osteoblast-derived metabolic hormones (osteocalcin, lipocalin and sclerostin) and the clinical evidence that suggests the relevance of these pathways in humans, while also discussing the necessity of specific energy substrates (glucose, fatty acids and amino acids) to fuel bone formation and promote osteoblast differentiation.
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U2 - 10.1038/s41574-019-0246-y
DO - 10.1038/s41574-019-0246-y
M3 - Review article
C2 - 31462768
AN - SCOPUS:85071919567
VL - 15
SP - 651
EP - 665
JO - Nature Clinical Practice Endocrinology and Metabolism
JF - Nature Clinical Practice Endocrinology and Metabolism
SN - 1759-5029
IS - 11
ER -