The role of nitric oxide in prostaglandin biology; Update

Research output: Contribution to journalReview articlepeer-review

Abstract

The biosynthesis of nitric oxide (NO) and prostaglandin share many similarities. Two major forms of nitric oxide synthase (NOS) and cyclooxygenase (COX) have been identified: constitutive versus inducible. In general, the constitutive form functions in housekeeping and physiologic roles whereas the inducible form is up-regulated by mitogenic or inflammatory stimuli and is responsible for pathophysiological responses. The cross talk between the COX and NOS pathways was initially reported in 1993 and since then, numerous studies have been undertaken to delineate the functional consequences of this interaction as well as the potential mechanism by which each pathway interacts. This review will focus in particular on recent advances in this field that extend our understanding of these two pathways under various systems.

Original languageEnglish (US)
Pages (from-to)255-264
Number of pages10
JournalNitric Oxide - Biology and Chemistry
Volume25
Issue number3
DOIs
StatePublished - Oct 30 2011
Externally publishedYes

Keywords

  • Cyclooxygenase
  • Nitric oxide
  • Nitric oxide synthase
  • Peroxynitrite
  • Prostaglandin
  • S-nitrosylation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cancer Research

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