The role of neutral proteinase and cathepsin D in turpentine induced inflammation

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9 Scopus citations


Intradermal injection of turpentine in peanut oil results in massive infiltration of skin by granulocytes within 24 hr. Acute inflammatory cells disappear over the next 4 days and by day 9 there is epithelial hyperplasia, round cell infiltration, and new vessel formation. There is a biphasic increase in cathepsin D and neutral proteinase activities coincident with granulocyte infiltration at day 2 and the granulomatous response at day 9. The sources of the elevation in neutral proteinase activity appear to be circulating inflammatory cells which have migrated to the skin, as well as the skin itself. Elevation of proteinase levels coincides with evidence of resorption of connective tissue macromolecules, suggesting that cathepsin D and neutral proteinase may play a role in dermal connective tissue catabolism.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalJournal of Investigative Dermatology
Issue number4
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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