The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity

Edwin J. Weeber, Michael Levy, Margaret J. Sampson, Keltoum Anflous, Dawna L. Armstrong, Sarah E. Brown, J. David Sweatt, William J. Craigen

Research output: Contribution to journalArticle

Abstract

Mitochondrial outer membrane permeability is conferred by a family of porin proteins. Mitochondrial porins conduct small molecules and constitute one component of the permeability transition pore that opens in response to apoptotic signals. Because mitochondrial porins have significant roles in diverse cellular processes including regulation of mitochondrial ATP and calcium flux, we sought to determine their importance in learning and synaptic plasticity in mice. We show that fear conditioning and spatial learning are disrupted in porin-deficient mice. Electrophysiological recordings of porin-deficient hippocampal slices reveal deficits in long and short term synaptic plasticity. Inhibition of the mitochondrial permeability transition pore by cyclosporin A in wild-type hippocampal slices reproduces the electrophysiological phenotype of porin-deficient mice. These results demonstrate a dynamic functional role for mitochondrial porins and the permeability transition pore in learning and synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)18891-18897
Number of pages7
JournalJournal of Biological Chemistry
Volume277
Issue number21
DOIs
StatePublished - May 24 2002
Externally publishedYes

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Porins
Neuronal Plasticity
Plasticity
Learning
Permeability
Mitochondrial Membranes
mitochondrial permeability transition pore
Cyclosporine
Fear
Adenosine Triphosphate
Fluxes
Calcium
Membranes
Phenotype
Molecules

ASJC Scopus subject areas

  • Biochemistry

Cite this

Weeber, E. J., Levy, M., Sampson, M. J., Anflous, K., Armstrong, D. L., Brown, S. E., ... Craigen, W. J. (2002). The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. Journal of Biological Chemistry, 277(21), 18891-18897. https://doi.org/10.1074/jbc.M201649200

The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. / Weeber, Edwin J.; Levy, Michael; Sampson, Margaret J.; Anflous, Keltoum; Armstrong, Dawna L.; Brown, Sarah E.; David Sweatt, J.; Craigen, William J.

In: Journal of Biological Chemistry, Vol. 277, No. 21, 24.05.2002, p. 18891-18897.

Research output: Contribution to journalArticle

Weeber, EJ, Levy, M, Sampson, MJ, Anflous, K, Armstrong, DL, Brown, SE, David Sweatt, J & Craigen, WJ 2002, 'The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity', Journal of Biological Chemistry, vol. 277, no. 21, pp. 18891-18897. https://doi.org/10.1074/jbc.M201649200
Weeber, Edwin J. ; Levy, Michael ; Sampson, Margaret J. ; Anflous, Keltoum ; Armstrong, Dawna L. ; Brown, Sarah E. ; David Sweatt, J. ; Craigen, William J. / The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. In: Journal of Biological Chemistry. 2002 ; Vol. 277, No. 21. pp. 18891-18897.
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