The Role of microRNA Markers in the Diagnosis, Treatment, and Outcome Prediction of Spinal Cord Injury

Nikolay L. Martirosyan, Alessandro Carotenuto, Arpan A. Patel, M. Yashar S. Kalani, Kaan Yagmurlu, G. Michael Lemole, Mark C. Preul, Nicholas Theodore

Research output: Contribution to journalReview article

Abstract

Spinal cord injury (SCI) is a devastating condition that affects many people worldwide. Treatment focuses on controlling secondary injury cascade and improving regeneration. It has recently been suggested that both the secondary injury cascade and the regenerative process are heavily regulated by microRNAs (miRNAs). The measurement of specific biomarkers could improve our understanding of the disease processes, and thereby provide clinicians with the opportunity to guide treatment and predict clinical outcomes after SCI. A variety of miRNAs exhibit important roles in processes of inflammation, cell death, and regeneration. These miRNAs can be used as diagnostic tools for predicting outcome after SCI. In addition, miRNAs can be used in the treatment of SCI and its symptoms. Significant laboratory and clinical evidence exist to show that miRNAs could be used as robust diagnostic and therapeutic tools for the treatment of patients with SCI. Further clinical studies are warranted to clarify the importance of each subtype of miRNA in SCI management.

Original languageEnglish (US)
Article number56
JournalFrontiers in Surgery
Volume3
DOIs
StatePublished - Nov 8 2016

Keywords

  • biomarker
  • gene expression
  • miRNA
  • microRNA
  • regeneration
  • spinal cord injury

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Martirosyan, N. L., Carotenuto, A., Patel, A. A., Kalani, M. Y. S., Yagmurlu, K., Lemole, G. M., Preul, M. C., & Theodore, N. (2016). The Role of microRNA Markers in the Diagnosis, Treatment, and Outcome Prediction of Spinal Cord Injury. Frontiers in Surgery, 3, [56]. https://doi.org/10.3389/fsurg.2016.00056