The role of major histocompatibility complex alleles in the susceptibility of Brazilian patients to develop the myogenic type of Graves' orbitopathy

Patricia Mitiko Santello Akaishi, Antonio Augusto Velasco Cruz, Fabricio Leon Mascaro Silva, Maria De Lourdes Veronesi Rodrigues, Lea Maria Zanini Maciel, Eduardo Antonio Donadi

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Abstract

Objective: To assess the frequency of the genetic markers HLA-DRB1 and DQB1 in patients with Graves' orbitopathy (GO) with and without extraocular muscle involvement. Design: The frequencies of class II HLA-DRB1 and DQB1 allele groups were determined for 81 Brazilian patients with GO and 161 normal subjects. The patients were divided into myogenic and nonmyogenic groups based on the clinical characteristics of the orbitopathy and quantitative computed tomography analysis of the extraocular muscle (EOM) dimensions. Main outcome: Compared to the frequency obtained for samples of normal subjects of the Brazilian population, HLA-DRB1*16 (pc = 0.008) was overrepresented in myogenic and HLA-DRB1*03 (pc = 0.02) in nonmyogenic patients. Conclusions: The association between the HLA-DRB1*16 and the myogenic subtype of GO suggests that EOM involvement in GO may be genetically predisposed.

Original languageEnglish (US)
Pages (from-to)443-447
Number of pages5
JournalThyroid
Volume18
Issue number4
DOIs
StatePublished - Apr 1 2008

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Akaishi, P. M. S., Cruz, A. A. V., Silva, F. L. M., Rodrigues, M. D. L. V., Maciel, L. M. Z., & Donadi, E. A. (2008). The role of major histocompatibility complex alleles in the susceptibility of Brazilian patients to develop the myogenic type of Graves' orbitopathy. Thyroid, 18(4), 443-447. https://doi.org/10.1089/thy.2007.0194