The role of inflammatory mediators in allergic rhinitis

R. Naclerio, D. Proud, S. Peters, A. K. Sobotka, L. Lichtenstein, Philip S. Norman

Research output: Contribution to journalArticle


We describe a nasal challenge model for allergic rhinitis. This model demonstrates the presence of inflammatory mediators during both the early and the late reactions following exposure to specific allergens. The mediators measured include histamine, TAME-esterase, kinin, leukotriene C4, and prostaglandin D2. A discussion of their role in the pathophysiology of allergic rhinitis is presented.

Original languageEnglish (US)
Pages (from-to)206-212
Number of pages7
JournalEar, nose, & throat journal
Issue number5
Publication statusPublished - 1986
Externally publishedYes


ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Naclerio, R., Proud, D., Peters, S., Sobotka, A. K., Lichtenstein, L., & Norman, P. S. (1986). The role of inflammatory mediators in allergic rhinitis. Ear, nose, & throat journal, 65(5), 206-212.