The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis nitric oxide

C. Zaragoza, C. Ocampo, M. Saura, M. Leppo, X. Q. Wei, R. Quick, S. Moncada, F. Y. Liew, C. J. Lowenstein

Research output: Contribution to journalArticlepeer-review

Abstract

The host response to Coxsackievirus infection is complex, including T lymphocytes, B lymphocytes, natural killer cells, and macrophages. Although Coxsackievirus infection induces expression of inducible nitric oxide synthase (NOS2; EC 1.14.13.39) in macrophages, the precise role of NOS2 in the host response to Coxsackievirus myocarditis has been unclear. We show, by using mice homozygous for a disrupted NOS2 allele, that Coxsackievirus replicates to higher titers in NOS2(-/-) mice, that the host lacking NOS2 clears virus more slowly than the wild-type host, and that myocarditis is much more severe in infected NOS2(-/-) mice. These data show that NOS2 is crucial for the host response to Coxsackievirus in the mouse.

Original languageEnglish (US)
Pages (from-to)2469-2474
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number5
DOIs
StatePublished - Mar 3 1998

Keywords

  • Nitric oxide

ASJC Scopus subject areas

  • Genetics
  • General

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