TY - JOUR
T1 - The role of IGF-1R in pediatric malignancies
AU - Kim, Su Young
AU - Toretsky, Jeffrey A.
AU - Scher, Daniel
AU - Helman, Lee J.
PY - 2009
Y1 - 2009
N2 - The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6). Members of this family regulate key cellular activities and they also play an important role in the development and progression of both adult and childhood cancers. Binding of a ligand to the receptor leads to its activation, followed by signal transduction along several pathways. In some childhood malignancies, IGF-1R can be activated by endocrine, autocrine, or paracrine mechanisms. Although mutations in IGF-1R have not been identified, this signaling pathway is upregulated in many childhood cancers. These findings have led to the development of a host of IGF-1R signaling modulators that are currently being tested in clinical trials. This review explores the role of IGF-1R in a range of childhood malignancies.
AB - The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6). Members of this family regulate key cellular activities and they also play an important role in the development and progression of both adult and childhood cancers. Binding of a ligand to the receptor leads to its activation, followed by signal transduction along several pathways. In some childhood malignancies, IGF-1R can be activated by endocrine, autocrine, or paracrine mechanisms. Although mutations in IGF-1R have not been identified, this signaling pathway is upregulated in many childhood cancers. These findings have led to the development of a host of IGF-1R signaling modulators that are currently being tested in clinical trials. This review explores the role of IGF-1R in a range of childhood malignancies.
KW - IGF-1R
KW - Molecular targeting
KW - Pediatric malignancy
KW - Therapeutic antibody
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U2 - 10.1634/theoncologist.2008-0189
DO - 10.1634/theoncologist.2008-0189
M3 - Article
C2 - 19126579
AN - SCOPUS:61449097712
SN - 1083-7159
VL - 14
SP - 83
EP - 91
JO - Oncologist
JF - Oncologist
IS - 1
ER -