The role of IGF-1R in pediatric malignancies

Su Young Kim, Jeffrey A. Toretsky, Daniel Scher, Lee J. Helman

Research output: Contribution to journalArticle

Abstract

The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6). Members of this family regulate key cellular activities and they also play an important role in the development and progression of both adult and childhood cancers. Binding of a ligand to the receptor leads to its activation, followed by signal transduction along several pathways. In some childhood malignancies, IGF-1R can be activated by endocrine, autocrine, or paracrine mechanisms. Although mutations in IGF-1R have not been identified, this signaling pathway is upregulated in many childhood cancers. These findings have led to the development of a host of IGF-1R signaling modulators that are currently being tested in clinical trials. This review explores the role of IGF-1R in a range of childhood malignancies.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalOncologist
Volume14
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Somatomedins
Pediatrics
Neoplasms
Insulin-Like Growth Factor Binding Protein 6
Ligands
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor II
Insulin Receptor
Insulin-Like Growth Factor I
Signal Transduction
Carrier Proteins
Clinical Trials
Mutation

Keywords

  • IGF-1R
  • Molecular targeting
  • Pediatric malignancy
  • Therapeutic antibody

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kim, S. Y., Toretsky, J. A., Scher, D., & Helman, L. J. (2009). The role of IGF-1R in pediatric malignancies. Oncologist, 14(1), 83-91. https://doi.org/10.1634/theoncologist.2008-0189

The role of IGF-1R in pediatric malignancies. / Kim, Su Young; Toretsky, Jeffrey A.; Scher, Daniel; Helman, Lee J.

In: Oncologist, Vol. 14, No. 1, 2009, p. 83-91.

Research output: Contribution to journalArticle

Kim, SY, Toretsky, JA, Scher, D & Helman, LJ 2009, 'The role of IGF-1R in pediatric malignancies', Oncologist, vol. 14, no. 1, pp. 83-91. https://doi.org/10.1634/theoncologist.2008-0189
Kim, Su Young ; Toretsky, Jeffrey A. ; Scher, Daniel ; Helman, Lee J. / The role of IGF-1R in pediatric malignancies. In: Oncologist. 2009 ; Vol. 14, No. 1. pp. 83-91.
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